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Dicloxacillin Sodium hydrate

目录号: PL12154 纯度: ≥98.0%

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素类的窄谱β内酰胺抗生素, 可用于革兰氏阳性菌感染的研究, 有效对抗β-内酰胺酶产生的微生物如金黄色葡萄球菌。

CAS No. :13412-64-1

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中文名称	Dicloxacillin Sodium hydrate
中文别名	双氯西林钠;双氯青霉素钠;双氯苯唑青霉素钠;(2S,5R,6R)-3,3-二甲基-6-[5-甲基-3-(2,6-二氯苯基)-4-异噁唑甲酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠;双氯青霉素钠(双氯西林);WAKO045-30481双氯西林钠标准品;全氟丁基磺酸锂;双氯青霉素钠盐;双氯青霉素钠盐水合物标准品;双氯西林钠 EP标准品;双氯西林钠 USP标准品;双氯西林钠标准品;双氯西林钠一水合物标准品;双氯西林钠杂质;(2S,5R,6R)-3,3-二甲基-6-[5-甲基-3-(2,6-二氯苯基)-4-异唑甲酰氨基]-7-氧代-4-硫杂-1-氮杂双环[3.2.0]庚烷-2-甲酸钠;双氟西林;双氯西林钠单水合物;双氯青霉素钠水合物;双氯西林钠(口服);双氯青霉素钠盐水合物;双氯青霉素钠一水合物
英文名称	Dicloxacillin Sodium hydrate
英文别名	dicloxacillin sodium monohydrate;Dicloxacillin Sodium;Cloxacillin Sodium;Dicloxacillin Sodium Salt Monohydrate;DICLOXACILLIN;Dicloxacillin sodium salt hydrate;Sodium 7-[3-(2,6-dichlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimet hyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylate;Dicloxacillin Sodium (500 mg);Dicloxacillin Sodium (300 mg);DICLOXACILLIN SODIUM WHO(CRM STANDARD);DICLOXACILLIN SODIUM USP(CRM STANDARD);DICLOXACILLIN SODIUM EPD(CRM STANDARD);Dicloxacillin monohydrate sodium salt;DICLOXACILLIN SODIUM SALT HYDRATE VETRAN;Dicloxacillin sodium hydrate solution,100ppm;Mesterolone;Dicloxacillin sodium monohydrate/Mesterolone;Dicloxacillin Sodium hydrate
Cas No.	13412-64-1
分子式	C₁₉H₁₇N₃O₅Scl₂^.Na+
分子量	493.32
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) 是青霉素类的窄谱β内酰胺抗生素, 可用于革兰氏阳性菌感染的研究, 有效对抗β-内酰胺酶产生的微生物如金黄色葡萄球菌。

产品详情

生物活性

Dicloxacillin Sodium hydrate (Dicloxacillin sodium salt monohydrate) is a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used to treat infections caused by susceptible Gram-positive bacteria, active against beta-lactamase-producing organisms such as Staphylococcus aureus.

性状

Solid

IC50 & Target[1][2]

β-lactam

体外研究(In Vitro)

Dicloxacillin exhibits EC50 values of 0.06 and 0.50 mg/L in ATCC 25923 and E19977, respectively. Dicloxacillin exhibits MIC values of 0.125 and 0.5 mg/L in ATCC 25923 and E19977 with pH 7.4, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">

体内研究(In Vivo)

Dicloxacillin exhibits therapeutic activity in murine peritonitis-sepsis model and all the mice are survivied. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female outbred Swiss Web

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Jusko WJ, et al. Enhanced renal excretion of dicloxacillin in patients with cystic fibrosis. Pediatrics. 1975 Dec;56(6):1038-44.
[2]. Miranda-Novales G, et al. In vitro activity effects of combinations of cephalothin, dicloxacillin, imipenem, vancomycin and amikacin against methicillin-resistant Staphylococcus spp. strains. Ann Clin Microbiol Antimicrob. 2006 Oct 12;5:25.

溶解度数据	In Vitro: H₂O : 25 mg/mL (48.99 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Dicloxacillin Sodium hydrate

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