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Cecropin A

目录号: PL12167 纯度: ≥99%

Cecropin A 是一种由 37 个氨基酸组成的线性多肽，具有抗菌、抗肿瘤及抗炎的功效。

CAS No. :80451-04-3

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中文名称	Cecropin A
中文别名	抗菌肽;抗菌肽A
英文名称	Cecropin A
英文别名	L-Lysinamide,L-lysyl-L-tryptophyl-L-lysyl-L-leucyl-L-phenylalanyl-L-lysyl-L-lysyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-valylglycyl-L-glutaminyl-L-asparaginyl-L-isoleucyl-L-arginyl-L-a-aspartylglycyl-L-isoleucyl-L-isoleucyl-L-lysyl-L-alanylglycyl-L-prolyl-L-alanyl-L-valyl-L-alanyl-L-valyl-L-valylglycyl-L-glutaminyl-L-alanyl-L-threonyl-L-glutaminyl-L-isoleucyl-L-alanyl-;CECROPIN A;L-Lysinamide,L-lysyl-L-tryptophyl-L-lysyl-L-leucyl-L-phenylalanyl-L-lysyl-L-lysyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-valylgly;L-Lysinamide,L-lysyl-L-tryptophyl-L-lysyl-L-leucyl-L-phenylalanyl-L-lysyl-L-lysyl-L-isoleucyl-L-a-glutamyl-L-lysyl-L-valylglycyl-L-glutaminyl-L-asparaginyl-L-isoleucyl-L-arginyl-L-a-aspartylglycyl-L-i;P9A Protein;CID 16132345;dsim protein, Drosophila;dyak protein, Drosophila;cecA1 protein, Drosophila;cecA2 protein, Drosophila;cecropin A2 protein, Drosphila;cecropin A1 protein, Drosophila;KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK-NH2;H-Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2
Cas No.	80451-04-3
分子式	C₁₈₄H₃₁₃N₅₃O₄₆
分子量	4003.78
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
详情描述	Cecropin A 是一种由 37 个氨基酸组成的线性多肽，具有抗菌、抗肿瘤及抗炎的功效。

产品详情	Cecropin A 是一种由 37 个氨基酸组成的线性多肽，具有抗菌、抗肿瘤及抗炎的功效。
生物活性	Cecropin A is a linear 37-residue antimicrobial polypeptide, with anticancer and anti-inflammatory activity.
性状	Solid
IC50 & Target[1][2]	Bacterial
体外研究(In Vitro)	Cecropin A shows anticancer activity. Cecropin A (10-50 μM) dose-dependently reduces the viability of HL-60 cells. Cecropin A (30 μM) promotes ROS production, causes mitochondrial membrane potential (Δψm) collapse, and generates morphological changes in nuclear chromatin in HL-60 cells. Cecropin A (30 μM) also leads to an early apoptosis and cuases caspase-independent cell death in HL-60 cells. Cecropin A has cytotoxicity on gram negative bacteria, including A. baumanii (CCARM 12005, CCARM 12035, CCARM 12036, CCARM 12037) with minimal inhibitory concentration (MIC) of 0.5-1 μM. Cecropin A (25 μM) significantly blocks the expression of mTNF-α, mIL-1β, and mMIP-2 mRNA and slightly inhibited the expression of mMIP-1 mRNA in RAW264.7 cells. Cecropin A (0.1, 0.25, 0.5, 1, 2.5, 5 μM) also inhibits NO production and reduces mTNF-α cytokine levels in LPS-stimulated RAW264.7 cel
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK-NH2
Sequence	Lys-Trp-Lys-Leu-Phe-Lys-Lys-Ile-Glu-Lys-Val-Gly-Gln-Asn-Ile-Arg-Asp-Gly-Ile-Ile-Lys-Ala-Gly-Pro-Ala-Val-Ala-Val-Val-Gly-Gln-Ala-Thr-Gln-Ile-Ala-Lys-NH2
参考文献	[1]. Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503. [2]. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.

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[1]. Cerón JM, et al. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides. 2010 Aug;31(8):1494-503.
[2]. Lee E, et al. Anti-inflammatory activities of cecropin A and its mechanism of action. Arch Insect Biochem Physiol. 2015 Jan;88(1):31-44.

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Cecropin A

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