BSH-IN-1 是一种重组的肠道细菌胆汁盐水解酶 (BSHs) 的有效和共价抑制剂，对 B. longum BSH (革兰氏阳性) 和 B. theta BSH (革兰氏阴性菌) 的 IC₅₀ 分别为 108 和 427 nM。

BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC 50 s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively.

Solid

BSH-IN-1 (Compound 7) also inhibits BSH activity in growing cultures of Gram-negative ( B. theta  VPI-5482,  Bacteroides fragilis  ATCC 25285, and  Bacteroides vulgatus ATCC 8482) and Gram-positive ( Lactobacillus plantarum  WCFS1,  C. perfringens  ATCC 13124, and  Bifidobacterium adolescentis  L2-32) bacteria. BSH-IN-1 (Compound 7) also is a potent BSH inhibitor in growing bacterial cultures with IC50s of 237 nM and 1070 nM for B. adolescentis (Gram positive) and B. theta (Gram negative), respectively. has not independently confirmed the accuracy of these methods. They are for reference only.

BSH-IN-1 (Compound 7; 10?mg/kg; a single dose; gavage) inhibits BSH activity in C57BL/6 mice and can be gut-restricted. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 mice

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases.Nat Chem Biol. 2020 Mar;16(3):318-326.

In Vitro: DMSO : 25 mg/mL (61.19 mM; ultrasonic and warming and heat to 80°C)配制储备液