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Hydroxystilbamidine bis(methanesulfonate)

目录号: PL12170 纯度: ≥96.0%

Hydroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料，也被发现是细胞核糖核酸酶的强效抑制剂。

CAS No. :223769-64-0

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中文名称	Hydroxystilbamidine bis(methanesulfonate)
中文别名	羟基脒双（甲磺酸）;羟芪巴脒;2-羟芪巴脒二甲烷磺酸盐
英文名称	Hydroxystilbamidine bis(methanesulfonate)
英文别名	Benzenecarboximidamide,4-[2-[4-(aminoiminomethyl)phenyl]ethenyl]-3-hydroxy-,dimethanesulfonate (salt);Hydroxystilbamidine bis(methanesulfonate);HydroxystilbaMidine bis(Methanesulfonate) [Know as FluoroGold(TM), TM of FluorochroMe];, TM of Fluorochrome];2-Hydroxystilbene-4,4′-dicarboxamidine bis(methanesulfonate);Fluoro-Gold™
Cas No.	223769-64-0
分子式	C₁₆H₁₆N₄O^.₂[CH₄O₃S]
分子量	472.54
包装储存	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
详情描述	Hydroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料，也被发现是细胞核糖核酸酶的强效抑制剂。

产品详情	Hydroxystilbamidine bis(methanesulfonate) 是一种能够结合 DNA 和 RNA 的染料，也被发现是细胞核糖核酸酶的强效抑制剂。
生物活性	Hydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases.
性状	Solid
体外研究(In Vitro)	It is found that the trypanocidal dye Hydroxystilbamidine bis(methanesulfonate) permits the recovery of mRNA after polysome released with Nonidet P-40 (NP-40). Sucrose gradient analysis of detergent-lysed postnuclear supernates is used to analyze the size distribution of NP-40-released polysomes. The heparin gradient shows some polyribosomes, whereas the Hydroxystilbamidine bis(methanesulfonate) gradient shows a remarkably large peak of very heavy polyribosomes. This peak is obtained reproducibly if Hydroxystilbamidine bis(methanesulfonate) is present before the addition of NP-40. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Hydroxystilbamidine bis(methanesulfonate) is an effective suppressor of the plaque-forming cell (PFC) response when given before sheep erythrocytes (SRBC) stimulation. Hydroxystilbamidine bis(methanesulfonate) depresses the plaque response of the treated mice. Fewer PFC are observed in Hydroxystilbamidine bis(methanesulfonate)-treated mice throughout the experiment, but the level of suppression decreases with time. By day 14, the number of PFC observed in both the Hydroxystilbamidine bis(methanesulfonate) treated mice and the control group is essentially at the background level. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Lizardi PM. Isolation of giant silk fibroin polysomes and fibroin mRNP particles using a novel ribonuclease inhibitor, hydroxystilbamidine. J Cell Biol. 1980 Oct;87(1):292-6. [2]. Folds JD, et al. Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug. Infect Immun. 1975 Mar;11(3):441-4.

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[1]. Lizardi PM. Isolation of giant silk fibroin polysomes and fibroin mRNP particles using a novel ribonuclease inhibitor, hydroxystilbamidine. J Cell Biol. 1980 Oct;87(1):292-6.
[2]. Folds JD, et al. Immunosuppression by hydroxystilbamidine isethionate, a lysosome-stabilizing, anti-proteolytic, antifungal drug. Infect Immun. 1975 Mar;11(3):441-4.

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Hydroxystilbamidine bis(methanesulfonate)

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