KIN101 是有效的 RNA 病毒 (RNA viral) 抑制剂，对流感病毒 (influenza virus) 和登革热病毒 (DNV) 的 IC₅₀ 分别为 2 μM，>5 μM。KIN101 是一种 IRF-3 依赖性信号传导的异黄酮激动剂，可以诱导 IRF-3 核易位。KIN101 具有针对 RNA 病毒的广谱活性。

KIN101 is a potent RNA viral inhibitor with IC 50 s of 2 μM, >5 μM for influenza virus and Dengue virus (DNV), respectively. KIN101, an isoflavone agonist of IRF-3 dependent signaling, induces IRF-3 nuclear translocation. KIN101 has broad-spectrum activity against RNA viruses.

Solid

IC50: 2 μM (influenza virus) and >5 μM (DNV)

KIN 101 (10 μM; 24 hours) causes a significant decrease in the NP protein abundance.
KIN 101 (10 μM; 18 hours) shows a >1 log decrease in HCV RNA levels.
KIN 101 (0.01, 0.1, 1, 10, 100 μM) has a significant and dose-dependent effect on the formation of foci and has an IC50 of 0.2 μM.
KIN 101 (5, 10, 20, 50 μM; 4 hours) causes a dose-dependent decrease in influenza virus infection in MRC5 cells.
KIN 101 results in a significant increase in the levels of ISGs as well as other proteins downstream of IRF activation such as RIG-I and MDA5.
KIN101 (0.1-100 μM; 18 hours) shows the antiviral activity against hepatitis C virus (HCV).
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Bedard KM, et al. Isoflavone agonists of IRF-3 dependent signaling have antiviral activity against RNA viruses. J Virol. 2012 Jul;86(13):7334-44.
[2]. Shawn P. Iadonato, et al. Anti-viral compounds, pharmaceutical compositions and methods of use thereof. US20160122312A1.

In Vitro: DMSO : 41.67 mg/mL (105.43 mM; ultrasonic and warming and heat to 60°C)配制储备液