BM635是 MmpL3 的抑制剂， 具有出色的抗分歧杆菌活性。抑制结合分歧杆菌H37Rv的MIC₅₀ 值为0.12 μM。

BM635 is a MmpL3 inhibitor with outstanding anti-mycobacterial activity. BM635 has an MIC 50 of 0.12 μM against M. tuberculosis H37Rv.

Solid

MIC50: 0.12 μM (M. tuberculosis H37Rv)

BM635 has potent MIC (0.12 μM), Tox 50 :MIC ratio of >100, and good microsomal stability in mice (1.4 mL/min/g). When tested in an acute murine infection model at multiple doses, BM635 exhibits potent anti-tubercular activity, with an ED 99 of 49 mg/Kg (IC 95% : 43–54 mg/Kg). The half-life in vivo of BM635 is 1h, allowing a reasonable maximum concentration (C max =1.62 μM) and a moderate bioavailability (46%). Its poor aqueous solubility together with its high lipophilicity leads to low exposure in vivo. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Poce G, et al. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One. 2013;8(2):e56980.
[2]. Poce G, et al. Pharmaceutical salt of BM635 with improved bioavailability. Eur J Pharm Sci. 2017 Mar 1;99:17-23.

In Vitro: DMSO : 31 mg/mL (78.98 mM; Need ultrasonic and warming)配制储备液