KB-5492 anhydrous|129200-10-8|-陌孚医药/Medlife

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KB-5492 anhydrous

目录号: PL11272 纯度: ≥99%

CAS No. :129200-10-8

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中文名称	KB-5492 anhydrous
英文名称	KB-5492 anhydrous
英文别名	4-methoxyphenyl [4-(3,4,5-trimethoxybenzyl)piperazin-1-yl]acetate (2E)-but-2-enedioate;but-2-enedioic acid,(4-methoxyphenyl) 2-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]acetate;KB-5492 anhydrous;KB 5492;1-Piperazineacetic acid, 4-((3,4,5-trimethoxyphenyl)methyl)-, 4-methoxyphenyl ester, (E)-2-butenedioate (1:1);1-(3,4,5-Trimethoxybenzyl)-4-((4-methoxyphenyl)oxycarbonylmethyl)piperazine;1-Piperazineacetic acid, 4-[(3,4,5-trimethoxyphenyl)methyl]-, 4-methoxyphenyl ester, (2E)-2-butenedioate (1:1) (9CI);(E)-but-2-enedioic acid;(4-methoxyphenyl) 2-[4-[(3,4,5-trimethoxyphenyl)methyl]piperazin-1-yl]acetate;4-Methoxyphenyl 4-((3,4,5-t
Cas No.	129200-10-8
分子式	C₂₇H₃₄N₂O₁₀
分子量	546.57
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	KB-5492 anhydrous 是一种有效的和选择性的 sigma 受体抑制剂，抑制 [³H]1,3-di(2-tolyl)guanidine (DTG) 与 sigma 受体结合，IC₅₀ 值为 3.15 μM。KB-5492 anhydrous 是一种抗溃疡剂。
生物活性	KB-5492 anhydrous is a potent and selective inhibitor of sigma receptor, inhibits specific [H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC 50 of 3.15 μM. KB-5492 anhydrous is an anti-ulcer agent.
性状	Solid
IC50 & Target[1][2]	IC50: 3.15 μM (sigma receptor)
体外研究(In Vitro)	KB-5492 (0.001-100 μM) inhibits specific [H]DTG binding in a concentration-dependent manner. KB-5492 (0.1-1 mM) significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in Cr release from gastric epithelial cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	KB-5492 (200?mg/kg; p.o.) prevents macroscopic lesions in the gastric mucosa. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats weighing 210-240 g are induced g
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Harada Y, et, al. Receptor binding profiles of KB-5492, a novel anti-ulcer agent, at sigma receptors in guinea-pig brain. Eur J Pharmacol. 1994 May 2; 256(3): 321-8. [2]. Morimoto Y, et, al. Effects of KB-5492, a new anti-ulcer agent, on ethanol- and acidified aspirin-induced gastric mucosal damage in vivo and in vitro. Jpn J Pharmacol. 1994 Jan; 64(1): 41-7.

溶解度数据	In Vitro: DMSO : 250 mg/mL (457.40 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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