Ripasudil|887375-67-9|(K-115)-陌孚医药/Medlife

您当前的位置：

Ripasudil (Synonyms: K-115)

目录号: PL11042 纯度: ≥98%

CAS No. :887375-67-9

商品编号	规格	价格	会员价
PL11042-2mg	2mg	¥1703.00	请登录
PL11042-5mg	5mg	¥2571.00	请登录
PL11042-10mg	10mg	¥4178.00	请登录
PL11042-25mg	25mg	¥9000.00	请登录
PL11042-50mg	50mg	¥15912.00	请登录
PL11042-100mg	100mg	询价	询价
PL11042-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2238.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Ripasudil
中文别名	(2S)-1-[(4-氟-5-异喹啉基)磺酰基]六氢-2-甲基-1H-1,4-二氮杂卓单盐酸盐二水合物;(S)-4-氟-5-((2-甲基-1,4-二氮杂卓-1-基)磺酰基)异喹啉盐酸盐二水合物
英文名称	Ripasudil
英文别名	K115;K-115 Hydrochloride Dihydrate;Ripasudil;K-115;Ripasudil hydrochloride dihydrate;016TTR32QF;Ripasudil hydrochloride hydrate [JAN];Ripasudil hydrochloride hydrate (JAN);Ripasudil hydrochloride hydrate;Glanatec (TN);Ripasudil hydrochloride dihydrate [WHO-DD];C15H18FN3O2S.ClH.2H2O;BCP11082;s7995;3757AH;1H-1,4-Diazepine, 1-((4-fluoro-5-is;1H-1,4-Diazepine, 1-[(4-fluoro-5-isoquinolinyl)sulfonyl]hexahydro-2-methyl-, monohydrochloride, dihydrate, (2S)- (9CI);Ripasudil monohydrochloride dihydrate
Cas No.	887375-67-9
分子式	C₁₅H₂₁ClFN₃O₃S
分子量	377.86
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Ripasudil (K-115) 是 ROCK 特异性抑制剂，能够抑制 ROCK2 和 ROCK1 的活性，IC₅₀ 值分别为 19 和 51 nM。

生物活性

Ripasudil (K-115) is a specific inhibitor of ROCK, with IC 50 s of 19 and 51 nM for ROCK2 and ROCK1, respectively.

性状

Solid

IC50 & Target[1][2]

ROCK2 19 nM (IC50) ROCK1 51 nM (IC50

体外研究(In Vitro)

Ripasudil (K-115) is a potent inhibitor of ROCK, with IC50s of 19 and 51 nM for ROCK2 and ROCK1, respectively. Ripasudil also shows less potent inhibitory activities against CaMKIIα, PKACα and PKC, with IC50s of 370 nM, 2.1 μM and 27 μM, respectively. Ripasudil (K-115; 1, 10 μM) induces cytoskeletal changes, including retraction and cell rounding and reduced actin bundles of cultured trabecular meshwork (TM) cells. Ripasudil (5 μM) sifnificantly reduces transendothelial electrical resistance (TEER), and increases FITC-dextran permeability in Schlemm’s canal endothelial (SCE) cell monolayers. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Ripasudil (K-115) reduces intraocular pressure (IOP) in a concentration-dependent manner at concentrations between 0.1% and 0.4% in monkey eyes and 0.0625% to 0.5% in rabbit eyes, respectively. Ripasudil (K-115; 1 mg/kg, p.o. daily) shows a neuroprotective effect on retinal ganglion cells (RGCs) after nerve crush (NC). Ripasudil also inhibits the oxidative stress induced by axonal injury in mice. Ripasudil suppresses the time-dependent production of ROS in RGCs after NC injury. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Isobe T, et al. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014 Aug;39(8):813-22.
[2]. Kaneko Y, et al. Effects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemms canal endothelial cells. Sci Rep. 2016 Jan 19;6:19640.

溶解度数据	In Vitro: H₂O : ≥ 50 mg/mL (126.30 mM)DMSO : 25 mg/mL (63.15 mM; Need ultrasonic)

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation