Sovesudil hydrochloride||(PHP-201 hydrochloride; AMA0076 hydrochloride)-陌孚医药/Medlife

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Sovesudil hydrochloride (Synonyms: PHP-201 hydrochloride; AMA0076 hydrochloride)

目录号: PL09096 纯度: ≥99%

商品编号	规格	价格	会员价
PL09096-5mg	5mg	¥8036.00	请登录
PL09096-10mg	10mg	¥13661.00	请登录
PL09096-50mg	50mg	询价	询价
PL09096-100mg	100mg	询价	询价

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中文名称	Sovesudil hydrochloride
英文名称	Sovesudil hydrochloride
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Sovesudil (PHP-201) hydrochloride 是一种有效的、ATP 竞争性局部作用 Rho 激酶 (ROCK) 抑制剂，对 ROCK I 和 ROCK II 的 IC₅₀ 分别为 3.7和2.3 nM。Sovesudil hydrochloride 可降低眼压而不引起充血。

生物活性

Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor with IC 50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil hydrochloride lowers intraocular pressure (IOP) without inducing hyperemia.

性状

Solid

IC50 & Target[1][2]

ROCK-I 3.7 nM (IC50) ROCK-II 2.3 nM (IC

体外研究(In Vitro)

Sovesudil (PHP-201) (1 μM; 60 min) hydrochloride is able to induce altered cellular behavior of human trabecular meshwork (HTM) cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Sovesudil (0.1%, 0.3%, and 0.5%; male New Zealand White rabbits) hydrochloride effectively reduces Intraocular Pressure (IOP) in ocular normotensive and acute hypertensive rabbits without causing distinct hyperemia. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Van de Velde S, et al. AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia. Invest Ophthalmol Vis Sci. 2014;55(2):1006-1016. Published 2014 Feb 18.
[2]. Ha A, et al. Sovesudil (locally acting rho kinase inhibitor) for the treatment of normal-tension glaucoma: the randomized phase II study [published online ahead of print, 2021 Jul 28]. Acta Ophthalmol. 2021;10.1111/aos.14949.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (140.80 mM; ultrasonic and warming and heat to 60°C)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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