PARP1-IN-5 dihydrochloride||-陌孚医药/Medlife

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PARP1-IN-5 dihydrochloride

目录号: PL08899 纯度: ≥97%

商品编号	规格	价格	会员价
PL08899-5mg	5mg	¥4018.00	请登录
PL08899-10mg	10mg	¥6107.00	请登录
PL08899-25mg	25mg	¥12054.00	请登录
PL08899-50mg	50mg	¥16876.00	请登录
PL08899-100mg	100mg	¥23305.00	请登录
PL08899-200mg	200mg	询价	询价
PL08899-500mg	500mg	询价	询价

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中文名称	PARP1-IN-5 dihydrochloride
英文名称	PARP1-IN-5 dihydrochloride
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	PARP1-IN-5 dihydrochloride 是一种低毒、具有口服活性、有效的和有选择性的 PARP-1 抑制剂(IC₅₀ =14.7 nM)。PARP1-IN-5 dihydrochloride 可用于癌症研究。
生物活性	PARP1-IN-5 dihydrochloride is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC 50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
性状	Solid
IC50 & Target[1][2]	PARP-1 14.7 nM (IC50) PARP-2 0.9 μM (IC
体外研究(In Vitro)	PARP1-IN-5 dihydrochloride (0.1~10 μM; A549 cells) can significantly increase the cytotoxicity of CBP on A549 cells in a dose-dependent manner. PARP1-IN-5 dihydrochloride (0.1~10 μM; SK-OV-3 cells) decreases the expressions of MCM2-7. PARP1-IN-5 dihydrochloride (0.1~320 μM; A549 cells) has little cytotoxic effects on A549 cells. PARP1-IN-5 dihydrochloride (SK-OV-3 cells) can significantly decrease the PAR level. PARP1-IN-5 dihydrochloride exerts antitumor effects through PARP-1. PARP1-IN-5 dihydrochloride could increase the γ-H2AX expression. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows that there is no significant difference in the body weight and blood routine. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1. PARP1-IN-5 dihydrochloride can upregulate the expression of γ-H2AX and decrease the expression of PAR. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Long H, et al. Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer. J Med Chem. 2021;64(16):12089-12108.

溶解度数据	In Vitro: DMSO : 125 mg/mL (232.58 mM; Need ultrasonic)H₂O : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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