MMAF hydrochloride|1415246-68-2|(Monomethylauristatin F hydrochloride)-陌孚医药/Medlife

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MMAF hydrochloride (Synonyms: Monomethylauristatin F hydrochloride)

目录号: PL07268 纯度: ≥99%

CAS No. :1415246-68-2

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PL07268-100mg	100mg	¥5464.00	请登录
PL07268-200mg	200mg	询价	询价
PL07268-500mg	500mg	询价	询价

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中文名称	MMAF hydrochloride
中文别名	MMAF (Hydrochloride)
英文名称	MMAF hydrochloride
英文别名	MMAF (Hydrochloride);Monomethylauristatin F Hydrochloride;MMAF Hydrochloride;(2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid;hydrochloride;monomethyl auristatin f hcl;MMAF hydrochloride
Cas No.	1415246-68-2
分子式	C₃₉H₆₆ClN₅O₈
分子量	768.42
包装储存	4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

产品详情	MMAF (Monomethylauristatin F) hydrochloride 是一种有效的微管蛋白聚合 (tubulin polymerization) 抑制剂，用作抗肿瘤药物。MMAF hydrochloride 广泛用作抗体偶联药物 (ADCs) 的细胞毒性成分，如 Vorsetuzumab mafodotin 和 SGN-CD19A。
生物活性	MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.
性状	Solid
IC50 & Target[1][2]	Auristatin
体外研究(In Vitro)	MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC50s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. Lee JW, et al. EphA2 targeted chemotherapy using an antibody drug conjugate in endometrial carcinoma. Clin Cancer Res. 2010 May 1;16(9):2562-70. [2]. Lee JJ, et al. Enzymatic prenylation and oxime ligation for the synthesis of stable and homogeneous protein-drug conjugates for targeted therapy. Angew Chem Int Ed Engl. 2015 Oct 5;54(41):12020-4.

溶解度数据	In Vitro: DMSO : 27 mg/mL (35.14 mM; Need ultrasonic and warming)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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