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MMAF-d8 (hydrochloride)

目录号: PL07262 纯度: ≥99%

商品编号	规格	价格	会员价
PL07262-1mg	1mg	¥17680.00	请登录
PL07262-5mg	5mg	询价	询价
PL07262-10mg	10mg	询价	询价

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中文名称	MMAF-d8 (hydrochloride)
英文名称	MMAF-d8 (hydrochloride)
包装储存	4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。

产品详情	MMAF-d₈ (hydrochloride)e是MMAF hydrochloride的氘代形式。
生物活性	MMAF-d 8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
性状	Solid
IC50 & Target[1][2]	Auristatin
体外研究(In Vitro)	MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur 该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献	[1]. Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.

溶解度数据	In Vitro: DMSO : 100 mg/mL (128.79 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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