Mebendazole|31431-39-7|(甲苯咪唑)-陌孚医药/Medlife

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Mebendazole (Synonyms: 甲苯咪唑)

目录号: PL07275 纯度: ≥99%

CAS No. :31431-39-7

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中文名称	Mebendazole
中文别名	甲苯咪唑;(5-苯甲酰-1-苯并咪唑-2-基)氨基甲酸甲酯;二苯酮胍甲酯;甲苯达唑;5-苯甲醯-2-苯并咪唑胺甲酸甲酯;甲苯哒唑;印楝油;2-[(2-氟苄基)氧基]苯甲醛;WAKO130-15201甲苯达唑标准品;甲苯达唑 USP标准品;甲苯咪唑 EP标准品;甲苯咪唑（MEB）标准品;甲苯咪唑标准品;甲苯咪唑多形体C;甲苯咪唑片;甲苯咪唑系统适应性 EP标准品;5-苯甲酰-2-苯并咪唑胺甲酸甲酯;N-(5-苯甲酰-1H-苯并咪唑-2-基)氨基甲酸甲酯;[5-(苯甲酰基)苯并咪唑-2-基]氨基甲酸甲酯
英文名称	Mebendazole
英文别名	Mebendazole;(5-Benzoyl-1H-benzimidazol-2-yl)carbamicacidmethylester;(5-benzoyl-1h-benzimidazol-2-yl)-carbamicacidmethylester;(5-benzoyl-1h-benzimidazol-2-yl)-carbamicacimethylester;5-benzoyl-2-benzimidazolecarbamicacimethylester;bantenol;besantin;lomper;mbdz;5-benzoyl-1H-benzimidazol-2-yl carbamic acid methyl ester;5-benzoyl-2-benzimidazolecarbamic acid methyl ester;mebenvet;Mebex;methyl (5-benzoyl-1H-benzimidazol-2-yl)carbamate(SALTDATA: FREE);Methyl (5-benzoyl-1H-benzo[d]imidazol-2-yl)carbamate;Methyl [5-(Benzoyl)benzimidazol-2-yl]carbamate;noverme;telmin;vermox;methyl 5-benzoylbenzimidazol-2-ylcarbamate;5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester;Methyl 5-benzoyl benzimidazole-2-carbamate
Cas No.	31431-39-7
分子式	C₁₆H₁₃N₃O₃
分子量	295.29
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

甲苯达唑是一种高效、广谱的抗线虫药。甲苯达唑对多形性乳腺母细胞瘤 (GBM) 也有抑制作用，抑制 Hedgehog 通路和微管蛋白 (tubulin) 聚合。甲苯达唑具有口服活性，可透过血脑屏障。

生物活性

Mebendazole is a highly effective, broad-spectrum antihelmintic against nematode infestations. Mebendazole also exhibits inhibitory effect against glioblastoma multiforme (GBM), inhibits Hedgehog pathway and tubulin polymerization. Mebendazole is orally active and can cross CNS penetration.

性状

Solid

IC50 & Target[1][2]

Tublin polymerization; Hedgehog; Parasite

体外研究(In Vitro)

Mebendazole (1 nM-0.1 mM; 72 h) shows inhibition of GL261 mouse glioma cells with IC value of 0.24 μM.
Mebendazole (0.1 μM and 1 μM; 24 h) disrupts microtubule polymerization and microtubule structure in 060919 glioblastoma multiforme (GBM) cells.
Mebendazole (10 nM-10 μM; 48 h) inhibits Hh signaling and reduces the expression of downstream Hh pathway effectors, by decreasing Gli1 transcript and protein expression in tumor tissues. Mebendazole inhibits Gli1 expression with an IC50 value of 516 nM.
Mebendazole (10 nM-10 μM; 48 h) prevents the formation of the primary cilium, and decreases the proliferation and survival of human medulloblastoma cells with constitutive Hh activation.
A combination of mebendazole and Vismodegib (HY-10440) achieved additive inhibition of canonical Hh signaling.
Mebendazole has effectively

体内研究(In Vivo)

Mebendazole (50 mg/kg; p.o.; once daily for first 20 d and 5 d per week with 2 d off; 45 d) inhibits intracranial tumor growth in the syngeneic GL261 mouse model and 060919 human glioblastoma multiforme (GBM) xenograft mouse model.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Bai RY, et al. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 2011 Sep;13(9):974-82.
[2]. Larsen AR, et al. Repurposing the antihelmintic mebendazole as a hedgehog inhibitor. Mol Cancer Ther. 2015 Jan;14(1):3-13.
[3]. Erdin?ler P, et al. The r

溶解度数据	In Vitro: DMSO : 4.17 mg/mL (14.12 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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