Vinflunine ditartrate|194468-36-5|-陌孚医药/Medlife

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Vinflunine ditartrate

目录号: PL07220

CAS No. :194468-36-5

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中文名称	Vinflunine ditartrate
中文别名	多抗霉素;甲基4-乙酰氧基-15-[16-(1,1-二氟乙基)-12-(甲氧羰基)-1,10-二氮杂四环[12.3.1.03,11.04,9]十八碳-3(11),4,6,8-四烯-12-基]-3-羟基-16-甲氧基-1-甲基-6,7-二去氢白坚木碱-3-羧酸酯2,3-二羟基;酒石酸长春氟宁
英文名称	Vinflunine ditartrate
英文别名	F 12158;Vinflunine Ditartrate;VINFLUNINE;Vinflunine Ditartrat;20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate;BMS 710485;Javlor;Ditartrate;(2β,3β,4β,5α,12β,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(Methoxycarbonyl)-2,6-Methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-Methoxy-1-MethylaspidosperMidine-3-carboxylic Acid Methyl Ester (2R,3R)-2,3-Dihydroxybutanedioate;20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate;Vinflunine ditartrate
Cas No.	194468-36-5
分子式	C₄₅H₅₄N₄O₈F₂^.₂[C₄H₆O₆]
分子量	1117.10
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Vinflunine ditartrate 是一种长春花生物碱家族的氟化微管抑制剂。Vinflunine ditartrate 具有抗血管生成，破坏血管和抗转移的活性。Vinflunine ditartrate 可用于尿路上皮移行细胞癌，非小细胞肺癌和乳腺癌的研究。

生物活性

Vinflunine ditartrate is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family. Vinflunine ditartrate has anti-angiogenic, vascular-disrupting and anti-metastatic activities. Vinflunine ditartrate can be used for the research of transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and carcinoma of the breast.

性状

Solid

IC50 & Target[1][2]

microtubule

体外研究(In Vitro)

Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology.
Vinflunine (0.01-10 μM; 1 h) disrupts newly formed capillary-like structures.
Vinflunine (0.01-10 μM; 1 h) inhibits endothelial cell motility, with an IC50 of 0.71 μM.
Vinflunine (0.001-10 μM; 1-72 h) inhibits endothelial cell proliferation in vitro.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Vinflunine (0.08-20 mg/kg; i.v.) reduces the number of experimental liver metastases by human LS174T colon cancer cells.
Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Bennouna J, et, al. Vinflunine: a new microtubule inhibitor agent. Clin Cancer Res. 2008 Mar 15;14(6):1625-32.
[2]. Kruczynski A, et, al. Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer. 2006 Nov;42(16):2821-32.

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Data Sheet

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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