Davunetide|211439-12-2|-陌孚医药/Medlife

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Davunetide

目录号: PL07279 纯度: ≥99%

CAS No. :211439-12-2

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中文名称	Davunetide
英文名称	Davunetide
英文别名	NAP Peptide;Davunetide;NAPVSIPQ;Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat;ASN-ALA-PRO-VAL-SER-ILE-PRO-GLN;NAP
Cas No.	211439-12-2
分子式	C₃₆H₆₀N₁₀O₁₂
分子量	824.92
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情

Davunetide 是一种八个氨基酸多肽，来源于活性依赖性神经保护蛋白 (ADNP)，一种存在于哺乳动物中枢神经系统中的神经营养因子。Davunetide 具有神经保护、神经营养和认知保护特性。Davunetide 是一种微管稳定肽 (microtubule-stabilizing)，在体外与神经元特异性βIII微管蛋白相互作用并稳定其活性。Davunetide 可透过血脑屏障，无毒。Davunetide 抑制Aβ聚集和Aβ诱导的神经毒性。

生物活性

Davunetide is an eight amino acid snippet derived from activity-dependent neuroprotective protein (ADNP), a neurotrophic factor that exists in the mammalian CNS. Davunetide possesses neuroprotective, neurotrophic and cognitive protective roperties. Davunetide, a microtubule-stabilizing peptide, interacts with and stabilises neuron-specific βIII-tubulin in vitro. Davunetide penetrates the blood-brain barrier and is non-toxic. Davunetide inhibits Aβ aggregation and Aβ-induced neurotoxicity.

性状

Solid

体内研究(In Vivo)

Davunetide (2 μg/kg; Intranasally; daily, 5 days a week, for 16 weeks) shows protective effects for central nervous system complications in a diabetes rat model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

ClinicalTrial

SequenceShortening

NAPVSIPQ

参考文献

[1]. Quraishe S, et al. NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry. 2013;18(7):834-842.
[2]. Zhang J, et al. Davunetide improves spatial learning and memory in Alzheimers disease-associated rats. Physiol Behav. 2017;174:67-73.
[3]. Idan-Feldman A, et al. Davuneti

溶解度数据	In Vitro: DMSO : 125 mg/mL (151.53 mM; Need ultrasonic)H₂O : 100 mg/mL (121.22 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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