Taltobulin trifluoroacetate|228266-41-9|(HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)-陌孚医药/Medlife

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Taltobulin trifluoroacetate (Synonyms: HTI-286 trifluoroacetate; SPA-110 trifluoroacetate)

目录号: PL07253 纯度: ≥99%

CAS No. :228266-41-9

商品编号	规格	价格	会员价
PL07253-5mg	5mg	询价	询价
PL07253-10mg	10mg	询价	询价
PL07253-10mM*1mLinDMSO	10mM*1mLinDMSO	询价	询价

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中文名称	Taltobulin trifluoroacetate
中文别名	化合物 T13073
英文名称	Taltobulin trifluoroacetate
英文别名	Taltobulin (trifluoroacetate);HTI-286 trifluoroacetate;SPA-110 trifluoroacetate;Taltobulin trifluoroacetate;A925487;(E,4S)-4-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(methylamino)-3-phenylbutanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid;2,2,2-trifluoroacetic acid;HTI-286 TRIFLUOROACETATE;SPA-110 TRIFLUOROACETATE
Cas No.	228266-41-9
分子式	C₂₉H₄₄F₃N₃O₆
分子量	587.67
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Taltobulin trifluoroacetate (HTI-286 trifluoroacetate) 是一种合成的三肽半胱氨酸类似物，Taltobulin 是一种有效的抗微管剂 (antimicrotubule)，可在体内外规避 P-糖蛋白介导的耐药性。Taltobulin trifluoroacetate 抑制纯化的微管蛋白聚合，破坏细胞中的微管组织，并诱导有丝分裂停滞以及凋亡 (apoptosis)。
生物活性	Taltobulin trifluoroacetate (HTI-286 trifluoroacetate), a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Taltobulin trifluoroacetate inhibits the polymerization of purified tubulin, disrupts microtubule organization in cells, and induces mitotic arrest, as well as apoptosis.
性状	Solid
IC50 & Target[1][2]	Traditional Cytotoxic Agents
体外研究(In Vitro)	Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Proliferation Assay-tbl">
体内研究(In Vivo)	Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice. Taltobulin (HTI-286; 3 mg/kg; p.o. gavage) inhibits growth by 97.3 % and 82% in athymic nu/nu female mice with Lox melanoma xenografts and KB-3-1 epidermoid xenograft model, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

溶解度数据	In Vitro: DMSO : ≥ 39 mg/mL (66.36 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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