Pifithrin-β hydrobromide|511296-88-1|(PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide)-陌孚医药/Medlife

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Pifithrin-β hydrobromide (Synonyms: PFT β hydrobromide; Cyclic Pifithrin-α hydrobromide)

目录号: PL07026 纯度: ≥99%

CAS No. :511296-88-1

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中文名称	Pifithrin-β hydrobromide
中文别名	环状抑制剂-α氢溴酸盐;2-(对甲苯基)-5,6,7,8-四氢咪唑并[2,1-b]苯并噻吩氢溴酸盐;（S）-（-）-2-甲氧基丙酰胺;Cyclic Pifithrin-alpha Hydrobromide ; 环状抑制剂-α氢溴酸盐;Pifithrin-β 抑制剂;环状抑制剂-α5,6,7,8-四氢-2-(4-甲基苯基)咪唑并[2,1-b]苯并噻唑氢溴酸盐
英文名称	Pifithrin-β hydrobromide
英文别名	Cyclic Pifithrin-α hydrobromide;Cyclic Pifithrin-alpha Hydrobromide;Pifithrin-β hydrobromide;2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole hydrobromide;Cyclic Pifithrin-Alpha (Hydrobromide);Cyclic Pifithrin-α (hydrobromide);2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothia zole hydrobromide (1:1);2-(p-Tolyl)-5,6,7,8-tetrahydroimidazo[2,1-b]benzothiazole Hydrobromide;Cyclic PFT-α hydrobromide;PFT-β hydrobromide;2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide;Pifithrin-α, cyclic;QB102;Pifithrin-beta hydrobromide;Pifithrin-;A hydrobromide;Pifithrin-alpha, Cyclic-;UP003XXT4D;Cyclic Pifithrin-;2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr;2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole;hydrobromide;Pifithrin-beta hydrobromide [MI];Cyclic PFT-;cyclic-pifithrin;PFT β hydrobromide
Cas No.	511296-88-1
分子式	C₁₆H₁₇BrN₂S
分子量	349.29
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Pifithrin-β hydrobromide (PFT β hydrobromide) 是有效地p53抑制剂，IC₅₀值为23 μM。
生物活性	Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC 50 of 23 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 23 μM (p53)
体外研究(In Vitro)	Pifithrin-α hydrobromide (PFT β hydrobromide), an inhibitor of the p53 protein, is regarded as a lead compound for cancer and neurodegenerative disease therapy. Pifithrin-α is very unstable in culture medium and rapidly converts to its condensation product pifithrin-β, the N-acetyl derivative. After 24 h, the viability assay shows that the pretreatments with 1 and 10 μM pifithrin-β exerts neuroprotective effects. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57. [2]. Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation productpifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.

溶解度数据	In Vitro: DMSO : 10 mg/mL (28.63 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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