p53 Activator 7 是一种 p53 突变 Y220C (MDM-2/p53) 激活剂，EC₅₀ 为 104 nM。p53 Activator 7 可以结合 p53 突变体并恢复其结合 DNA 的能力 (WO2022213975A1; Example B-1)。

p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC 50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1).

Solid

EC50: 104 nM (p53 mutation Y220C)

The p53 protein, referred to as the “guardian of the human genome” , is a tetrameric transcription factor that prevents mutation to the genome by regulating the expression of a subgroup of target genes. Although biologically active as a homotetramer, each p53 monomer is comprised of 393 amino acids, and is divided into five key regulatory domains: the transactivation domain (TAD) , proline-rich region (PR) , the DNA binding domain (DBD) , the oligomerization domain (OD) , and the C-terminus. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

[1]. Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1.

In Vitro: DMSO : 100 mg/mL (193.60 mM; Need ultrasonic)配制储备液