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Bidisomide

目录号: PL06131 纯度: ≥99%

Bidisomide (SC40230) 是一种 I 类抗心律失常剂。

CAS No. :116078-65-0

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中文名称	Bidisomide
中文别名	比地索胺
英文名称	Bidisomide
英文别名	1-Piperidinebutanamide,a-[2-[acetyl(1-methylethyl)amino]ethyl]-a-(2-chlorophenyl)-;4-[Acetyl(isopropyl)amino]-2-(2-chlorophenyl)-2-[2-(1-piperidinyl )ethyl]butanamide;SC40230;SC-40230;Bidisomide;Bidisomida;Bidisomidum;Brn 6536016;Bidisomidum [inn-latin];Bidisomida [inn-spanish];(αR)-α-[2-(Acetylisopropylamino)ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide;(αS)-α-[2-(Acetylisopropylamino)ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide;(S)-α-[2-[Acetyl(isopropyl)amino]ethyl]-α-(2-chlorophenyl)-1-piperidinebutanamide
Cas No.	116078-65-0
分子式	C₂₂H₃₄N₃O₂Cl
分子量	407.98
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	Bidisomide (SC40230) 是一种 I 类抗心律失常剂。

产品详情	Bidisomide (SC40230) 是一种 I 类抗心律失常剂。
生物活性	Bidisomide (SC40230) is a class I antiarrhythmic agent.
性状	Solid
体内研究(In Vivo)	The antiarrhythmic effects of Bidisomide, a new class I antiarrhythmic drug is investigated in early-phase ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats. Bidisomide (5 mg/kg) reduces the number of premature ventricular complexes and the incidence of ventricular tachycardia and ventricular fibrillation similarly to Mexiletine (MXT) and Disopyramide (DSP) in rats with ventricular arrhythmias induced by coronary artery occlusion. In rats with ventricular arrhythmias induced by coronary artery reperfusion following a 5 min coronary occlusion, the antiarrhythmic effects of 5 mg/kg of Bidisomide are similar to those of the same doses of MXT and DSP. All three drugs significantly slow the heart rate. has not independently confirmed the accuracy of these methods. They are for
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Komori S, et al. Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessels. 1995;1

溶解度数据	In Vitro: DMSO : 250 mg/mL (612.78 mM; Need ultrasonic)配制储备液

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[1]. Komori S, et al. Effects of bidisomide (SC-40230), a new class I antiarrhythmic agent, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats; comparison with mexiletine and disopyramide. Heart Vessels. 1995;1

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Bidisomide

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