A 71915|132956-87-7|-陌孚医药/Medlife

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A 71915

目录号: PL05926 纯度: ≥99%

CAS No. :132956-87-7

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中文名称	A 71915
中文别名	H-ARG-CYS-CHA-GLY-GLY-ARG-ILE-ASP-ARG-ILE-D-TIC-ARG-CYS-NH2 (DISULFIDE BRIDGE: CYS2-CYS13);化合物 T26437;(ARG6,Β-CYCLOHEXYL-ALA8,D-TIC16,ARG17,CYS18)-ATRIAL NATRIURETIC FACTOR (6-18) AMIDE (MOUSE, RABBIT, RAT) TRIFLUOROACETATE SALT;A288395] A 71915TFA,NPRA拮抗剂;A 71915 TFA,NPRA拮抗剂;A-71915\|\|\|A71915;化合物 A 71915
英文名称	A 71915
英文别名	(Arg?,β-cyclohexyl-Ala?,D-Tic1?,Arg1?,Cys1?)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat);(Arg?00β-cyclohexyl-Ala?00D-Tic??00Arg??00Cys??)-AtrialNatriureticFactor(6-18)amide(mouse00rabbit00rat);(Arg6,β -cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)- Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat);(Arg⁶,β-cyclohexyl-Ala⁸,D-Tic¹⁶,Arg¹⁷,Cys¹⁸)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat);A 71915;H-Arg-Cys-b-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2;(Arg6,b-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) aMide (Mouse, rabbit, rat);A71915;2-[(3S,6S,9S,12S,15R,24S,27R,31R,32R,38R)-27-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]ami
Cas No.	132956-87-7
分子式	C₆₉H₁₁₆N₂₆O₁₅S₂
分子量	1613.96
包装储存	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye

产品详情	A 71915 是一种具有高效、竞争性的 natriuretic peptide receptor A (ANP, NPRA) 拮抗剂 (pK_i= 9.18). A71915 的剂量依赖性取代 [¹²⁵I]ANP，K_i为0.65 nM。A71915 (pA₂= 9.48) 对大鼠 ANP 诱导的 NB-OK-1 细胞产生 cGMP 的作用。
生物活性	A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pK i = 9.18). A 71915 displaces [I]ANP dose dependently, with a K i of 0.65 nM. A71915( pA 2 = 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
性状	Solid
IC50 & Target[1][2]	A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18.
体外研究(In Vitro)	A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay. A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and light, under nitrogenPowder -80°C 2 years；-20°C 1 ye
SequenceShortening	{RC-Cha}-GGRIDRI-{D-Tic-RC}-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence	Arg-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)
参考文献	[1]. Delporte C, et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992;224(2-3):183-188. [2]. Kiguchi N, et al. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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