LCKLSL hydrochloride||-陌孚医药/Medlife

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LCKLSL hydrochloride

目录号: PL05957 纯度: ≥99%

商品编号	规格	价格	会员价
PL05957-5mg	5mg	¥4018.00	请登录
PL05957-10mg	10mg	¥7232.00	请登录
PL05957-25mg	25mg	¥13661.00	请登录
PL05957-50mg	50mg	询价	询价
PL05957-100mg	100mg	询价	询价

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中文名称	LCKLSL hydrochloride
英文名称	LCKLSL hydrochloride
包装储存	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year

产品详情	LCKLSL hydrochloride 是一种 N 末端六肽，是一种竞争性的膜联蛋白 A2 (AnxA2) 抑制剂，可有效抑制组织纤溶酶原激活物 (tPA) 与 AnxA2 的结合。LCKLSL hydrochloride 还可抑制纤溶酶的产生，并具有抗血管生成的作用。
生物活性	LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the binding of tissue plasminogen activator (tPA) to AnxA2. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles.
性状	Solid
IC50 & Target[1][2]	Annexin A2 (AnxA2)
体外研究(In Vitro)	In human retinal microvascular endothelial cells (RMVECs), treatment with LCKLSL (0-2 mg) inhibits the generation of plasmin and suppresses the VEGF-induced activity of tPA under hypoxic conditions. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Application of LCKLSL in two in vivo models (in chicken chorioallantoic membrane and murine Matrigel plug assays) of angiogenesis demonstrates suppression of the angiogenic responses. Treatment with the LCKLSL peptide significantly decreases the vascular length. At a dose of 5 μg/mL, the LCKLSL peptide significantly decreases the number of vascular branches, junctions and end-points. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisture and lightPowder -80°C 2 years；-20°C 1 year
SequenceShortening	LCKLSL
Sequence	Leu-Cys-Lys-Leu-Ser-Leu
参考文献	[1]. Mallika Valapala, et al. A Competitive Hexapeptide Inhibitor of Annexin A2 Prevents Hypoxia-Induced Angiogenic Events. J Cell Sci. 2011 May 1;124(Pt 9):1453-64.

溶解度数据	In Vitro: DMSO : 25 mg/mL (35.10 mM; Need ultrasonic)H₂O : 10 mg/mL (14.04 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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