Nattokinase|133876-92-3|-陌孚医药/Medlife

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Nattokinase

目录号: PL05959

CAS No. :133876-92-3

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中文名称	Nattokinase
中文别名	纳豆激酶;DL-3-(1-乙酰氧基-1-甲基乙基)-6-氧庚腈;纳豆红麴
英文名称	Nattokinase
英文别名	NattoLife;Nattokinase;Nattoesse Haruno-Ogawa;MLN9708;4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;Ixazomib Citrate (MLN9708);ixazomib citrate 1,3,2-dioxaborinane;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;4-(carboxymethyl)-2-[(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;1,3,2-Dio
Cas No.	133876-92-3
分子式	C₂₀H₂₃BCl₂N₂O₉
分子量	517.12
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情

Nattokinase 是一种有效的纤溶酶，可通过直接水解纤维蛋白和纤溶酶底物来分解血凝块。Nattokinase 可用于研究心血管疾病。

生物活性

Nattokinase is a potent fibrinolytic enzyme. Nattokinase can break down blood clots by directly hydrolyzing fibrin and plasmin substrate. Nattokinase can be used for the research of cardiovascular diseases.

性状

Solid

体外研究(In Vitro)

Nattokinase dissolves 94% blood clot at ten minutes and degrades the fibrin clot after two hours of incubation. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Nattokinase (150-250 mg/kg; oral gavage twice daily for 2 days) exhibits fibrinolytic activity and dissolves blood clots in vivo. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Sprag

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

ClinicalTrial

参考文献

[1]. Weng Y, et, al. Nattokinase: An Oral Antithrombotic Agent for the Prevention of Cardiovascular Disease. Int J Mol Sci. 2017 Feb 28; 18(3):523.
[2]. Chandrasekaran SD, et, al. Exploring the In Vitro Thrombolytic Activity of Nattokinase From a New Strain Pseudomonas aeruginosa CMSS. Jundishapur J Microbiol. 2015 Oct 26; 8(10): e23567.

溶解度数据	In Vitro: H₂O : 100 mg/mL (Need ultrasonic)In Vivo:

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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