NCI172112 是一种经典的双功能烷化剂，是为了开发有效抗中枢神经系统肿瘤而合成的一种抗肿瘤剂。

NCI172112 is a classical bifunctional alkylating agent synthesized in an effort to develop antitumor agents effective against CNS tumors.

Solid

NCI172112 (Spirohydantoin mustard, SHM) might serve as a carrier to cross the blood brain barrier. The cumulative excretion of radioactivity in the urine and faeces of rats after administration of [2-chloroethyl-U-C]NCI172112 or [hydantoin-4-C]NCI172112 ( 3.13 mg/kg. i.v.) is measured. Four hours after dosing, a significantly (P<0.005) greater amount of radioactivity has been excreted in the urine of rats treated with [hydantoin-C]NCI172112 than with [ethyl-C]NCI172112. However, by 24 h, approx.50% of dose is recovered in the urine with both labelled materials. Clearance of radioactivity in the faeces is slow, but, as for the renal excretion, is significantly greater for the hydantoin-C moiety. No radioactivity is found in the expired air of a rat receiving a single dosing of [hydantoin-C]NCI172112 and less than 1% is measured after administration of [ethyl-C]NCI172112. Ren

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Brown TD, et al. A phase I trial of spirohydantoin mustard (NSC 172112) in patients with advanced cancer. J Clin Oncol. 1986 Aug;4(8):1270-6.
[2]. Plowman J, et al. The disposition of spirohydantoin mustard (NSC 172112) in rats and dogs. Xenobiotica. 1979 Jun;9(6):379-91.

In Vitro: DMSO : 100 mg/mL (297.39 mM; Need ultrasonic)配制储备液