Phosphoramide mustard (cyclohexanamine)|1566-15-0|-陌孚医药/Medlife

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Phosphoramide mustard (cyclohexanamine)

目录号: PL03667 纯度: ≥95%

CAS No. :1566-15-0

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中文名称	Phosphoramide mustard (cyclohexanamine)
中文别名	N,N-二(2-氯乙基)二氨基磷酸环己基铵盐;磷酰胺芥盐环己胺
英文名称	Phosphoramide mustard (cyclohexanamine)
英文别名	N,N-bis(2-chloroethyl)phosphorodiamidic acid compound with cyclohexanamine (1:1);PHOSPHORAMIDEMUSTARD;amino-[bis(2-chloroethyl)amino]phosphinic acid,cyclohexanamine;MOEXIPRILAT HYDROCHLORIDE;N,N-BIS(2-CHLOROETHYL)PHOSPHORODIAMIDIC ACID CYCLOHEXYLAMINE SALT;cyclohexylamine, salt of;N,N-bis-(2-chloro-ethyl)-diamidophosphoric acid;n,n-bis(2-chloroethyl)phosphorodiamidic acid- cyclohexanamine(1:1);N,N-bis(2-chloroethyl)phosphorodiamidic acid cyclohexylammonium salt;NSC69945;phosphoramide mu;Phosphoramide mustard cyclohexamine salt;Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, compd. with cyclohexanamine (1:1);the;Phosphoramide mustard (cyclohexanamine)
Cas No.	1566-15-0
分子式	C₄H₁₁N₂O₂PCl₂^.C₆H₁₃N
分子量	320.20
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

产品详情	Phosphoramide mustard cyclohexanamine 是环磷酰胺 (HY-17420) 的活性代谢物，具有抗肿瘤活性。Phosphoramide mustard cyclohexanamine 能诱导 DNA 损伤。
生物活性	Phosphoramide mustard cyclohexanamine is a biologically active metabolite of Cyclophosphamide (HY-17420), with anticancer activitiy. Phosphoramide mustard cyclohexanamine induces DNA damage.
性状	Solid
体外研究(In Vitro)	Phosphoramide mustard cyclohexanamine causes cytotoxicity through forming cross-linked DNA adducts which inhibit DNA strand separation during replication. Phosphoramide mustard cyclohexanamine (3-6 μM; 48 hours) reduces cell viability in rat spontaneously immortalized granulosa cells (SIGCs). Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) induces DNA adduct formation and ovarian DNA damage. Phosphoramide mustard cyclohexanamine (3-6 μM; 24-48 hours) increases DNA damage responses (DDR) gene mRNA expression levels and DDR proteins. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Phosphoramide mustard cyclohexanamine (2.1-20.7 mg/kg; i.p.; daily; for 5 days) inhibits subcutaneous tumor growth in rats. Phosphoramide mustard cyclohexanamine exhibits terminal elimination half-lives (rat 15.1 min) following intravenous administration (rat 59.4 mg/kg). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Shanthi Ganesan, et al. Phosphoramide mustard exposure induces DNA adduct formation and the DNA damage repair response in rat ovarian granulosa cells. Toxicol Appl Pharmacol. 2015 Feb 1; 282(3): 252–258. [2]. S Genka, et al. Brain and plasma pharmacokinetics and anticancer activities of cyclophosphamide and phosphoramide mustard in the rat. Cancer Chemother Pharmacol. 1990;27(1):1-7.

溶解度数据	In Vitro: H₂O : 100 mg/mL (312.30 mM; Need ultrasonic)配制储备液

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