Miriplatin|141977-79-9|(SM-11355)-陌孚医药/Medlife

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Miriplatin (Synonyms: SM-11355)

目录号: PL04611 纯度: ≥98%

CAS No. :141977-79-9

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中文名称	Miriplatin
中文别名	米铂;顺[((1R,2R)-1,2-环己二胺-N,N')二(十四烷酰氧基)]合铂
英文名称	Miriplatin
英文别名	Platinum,[(1R,2R)-1,2-cyclohexanediamine-kN1,kN2]bis(tetradecanoato-kO)-, (SP-4-2)-;Miriplatin;cyclohexane-1,2-diamine,platinum(4+),tetradecanoate;SM-11355;UNII-780F0P8N4I;[(1R,2R)-1,2-Cyclohexanediamine]bis(myristato)platinum
Cas No.	141977-79-9
分子式	₂[C₁₄H₂₇O₂-]^.C₆H₁₄N₂^.Pt+₄
分子量	763.99
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Miriplatin (SM-11355) 为有效的化疗剂，是烷化剂 (alkylator) 的一种。
生物活性	Miriplatin (SM-11355) is a chemotherapy agent which belongs to the class of alkylating agents.
性状	Solid
体外研究(In Vitro)	Miriplatin (SM-11355) suspended in LPD (miriplatin/LPD, 100 μg/mL) inhibits the growth of AH109A cells, forms platinum-DNA adducts, and induces apoptosis. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Miriplatin (SM-11355) (0.02-0.4 mg/20 μL) in lipiodol reduces tumor growth rates in a dose dependent manner in rats bearing AH109A tumor cells. Miriplatin/LPD (400 μg/head) significantly reduces the growth of tumor in rats bearing AH109A cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kishimoto S, et al. Antitumor effects of a novel lipophilic platinum complex (SM-11355) against a slowly-growing rat hepatic tumor after intra-hepatic arterial administration. Biol Pharm Bull. 2000 Mar;23(3):344-8. [2]. Hanada M, et al. Intra-hepatic arterial administration with miriplatin suspended in an oily lymphographic agent inhibits the growth of tumors implanted in rat livers by inducing platinum-DNA adducts to form and massive apoptosis. Cancer Chemother Pharmaco

溶解度数据	In Vitro: Acetone : < 1 mg/mL (ultrasonic) (insoluble; DMSO can inactivate Miriplatins activity)DMF : < 1 mg/mL (insoluble; DMSO can inactivate Miriplatins activity)H₂O : < 0.1 mg/mL (insoluble; DMSO can inactivate Miriplatins activity) Miriplatin is usually formulated as a suspension.

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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