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N-Nitroso-N-methylurea

(Synonyms: 甲基亚硝基脲; NMU; MNU; NMH)

目录号: PL05028 纯度: ≥98%

N-Nitroso-N-methylurea (NMU;MNU;NMH) 是一种有效的致癌剂，诱变剂和致畸剂。N-Nitroso-N-methylurea 是一种直接作用的烷基化剂，与 DNA 相互作用。N-Nitroso-N-methylurea 靶向多种动物器官，以引起各种癌症和/或变性疾病。N-Nitroso-N-methylurea 也是一种重氮甲烷合成中的前体物质。

CAS No. :684-93-5

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中文名称	N-Nitroso-N-methylurea
中文别名	甲基亚硝基脲;N-甲基-N-亚硝基脲;N-亚硝基-N-甲基脲;1-甲基-1-亚硝基脲;亚硝基甲脲
英文名称	N-Nitroso-N-methylurea
英文别名	1-Methyl-1-nitrosourea;1-nitroso-1-methylurea;MNU;Nitrosomethylurea;n-methyl-n-nitroso-carbamide;N-methyl-N-nitroso-Urea;NMH;NMM;NMU;N-Nitrosomethylurea - Carc.;N-nitroso-N-methylcarbamide;N-Nitroso-N-Methylurea;ski 24464;sri 859;N-Methyl-N-nitrosourea;N-Methyl-N-nitroso U;N-Methyl-N-nitroso Urea (Contains Water);N-Nitroso-N-methylurea500µg;1-methyl-1-nitroso-urea;Urea,1-methyl-1-nitroso- (6CI,8CI);Methylnitrosourea;NSC 23909;Urea, N-methyl-N-nitroso-;Methylnitrosouree;N-Nitroso-N-methyl urea;Methylnitroso-harnstoff;Urea, 1-methyl-1-nitroso-;RCRA waste number U177;NMH [German];Urea, methylnitroso-;N-Methyl-N-nitroso-harnstoff;N-Nitroso-N-methyl-harnstoff;Carbamide, N-methyl-N-nitroso-;Methylnitrosouree [French];1-Methyl;1-Nitroso-1-methylurea;N-Nitroso-N-methylcarbamide;N-Nitroso-N-methylurea
Cas No.	684-93-5
分子式	C₂H₅N₃O₂
分子量	103.08
包装储存	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
详情描述	N-Nitroso-N-methylurea (NMU;MNU;NMH) 是一种有效的致癌剂，诱变剂和致畸剂。N-Nitroso-N-methylurea 是一种直接作用的烷基化剂，与 DNA 相互作用。N-Nitroso-N-methylurea 靶向多种动物器官，以引起各种癌症和/或变性疾病。N-Nitroso-N-methylurea 也是一种重氮甲烷合成中的前体物质。

产品详情	N-Nitroso-N-methylurea (NMU;MNU;NMH) 是一种有效的致癌剂，诱变剂和致畸剂。N-Nitroso-N-methylurea 是一种直接作用的烷基化剂，与 DNA 相互作用。N-Nitroso-N-methylurea 靶向多种动物器官，以引起各种癌症和/或变性疾病。N-Nitroso-N-methylurea 也是一种重氮甲烷合成中的前体物质。
生物活性	N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.
性状	Solid
体外研究(In Vitro)	N-Nitroso-N-methylurea (NMU; 5 μM) treatment increases the cellular NF-κB activity in human malignant keratinocytes. N-Nitroso-N-methylurea also increases the amount of I-κBα phosphorylation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	N-Nitroso-N-methylurea (NMU) gives intravenously to rats at age 50 days induced mammary carcinomas in 89% of BUF/N, 73% of Sprague-Dawley, and 89% of F344 females. Latent periods are, respectively, 77, 86, and 94 days. Doubling times of NMU-induced primary and transplanted carcinomas are similar to 7 days. Cachexia ensues at the 5th week from the onset of the first tumor. When the tumor is larger than 15 g, hypercalcemia is usually observed. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Gullino PM, et al. N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst. 1975 Feb;54(2):401-14. [2]. Tsubura A, et al. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011 Jan-Feb;25(1):11-22. [3].

溶解度数据	In Vitro: DMSO : 250 mg/mL (2425.30 mM; Need ultrasonic)H₂O : 50 mg/mL (485.06 mM; Need ultrasonic)配制储备液

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[1]. Gullino PM, et al. N-nitrosomethylurea as mammary gland carcinogen in rats. J Natl Cancer Inst. 1975 Feb;54(2):401-14.
[2]. Tsubura A, et al. Review: Animal models of N-Methyl-N-nitrosourea-induced mammary cancer and retinal degeneration with special emphasis on therapeutic trials. In Vivo. 2011 Jan-Feb;25(1):11-22.
[3].

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

N-Nitroso-N-methylurea

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