Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen.
性状
Solid-liquid mixture
体外研究(In Vitro)
Methylnitronitrosoguanidine (MNNG, 0-1100 nM; 24 h) has toxic and mutagenic effects among 3 human diploid lymphoblast lines, MIT-2, WI-L2, and GM 130. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Methylnitronitrosoguanidine (MNNG; 200 mg/kg; p.o.) stimulates Wistar albino rats and increases the number of gastric cancer rats. has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: Male
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years;4°C 2 years
参考文献
[1]. Slapikoff SA, et, al. Comparison of toxicity and mutagenicity of methylnitrosourea, methylnitronitrosoguanidine and ICR-191 among human lymphoblast lines. Mutat Res. 1980 May;70(3):365-71.[2]. Zhang L, Jia B, et, al. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environ Toxicol. 2022 May;37(5):1222-1230.
溶解度数据
In Vitro: DMSO : 125 mg/mL (849.82 mM; Need ultrasonic)配制储备液