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Trimetazidine-d8 (dihydrochloride)

目录号: PL05440 纯度: ≥99%

Trimetazidine-d8 (dihydrochloride) 是 Trimetazidine dihydrochloride 的氘代物。Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC50 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

CAS No. :1219795-37-5

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中文名称	Trimetazidine-d8 (dihydrochloride)
中文别名	盐酸曲美他嗪-D8氘代内标;(S)-2-(三氟甲基)吡咯烷;[ 2H8 ] - 盐酸曲美他嗪标准品;三甲氧苄嗪-d82盐酸盐(哌嗪-d8);盐酸曲美他嗪-D8;曲美他嗪二盐酸盐 D8;曲美他嗪-D8盐酸;曲美他嗪杂质1 二盐酸盐
英文名称	Trimetazidine-d8 (dihydrochloride)
英文别名	Trimetazidine-d8 2HCl (piperazine-d8);Trimetazidine dihydrochloride salt;Trimetazidine D8 dihydrochlorideQ: What is Trimetazidine D8 dihydrochloride Q: What is the CAS Number of Trimetazidine D8 dihydrochloride Q: What is the storage condition of Trimetazidine D8 dihydrochloride Q: What are the applications of Trimetazidine D8 dihydrochloride;Trimetazidine Impurity 1 DiHCl
Cas No.	1219795-37-5
分子式	C₁₄H₂₃ClN₂O₃
分子量	302.80
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
详情描述	Trimetazidine-d8 (dihydrochloride) 是 Trimetazidine dihydrochloride 的氘代物。Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC50 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

产品详情	Trimetazidine-d₈ (dihydrochloride) 是 Trimetazidine dihydrochloride 的氘代物。Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC₅₀ 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。
生物活性	Trimetazidine-d 8 (dihydrochloride) is the deuterium labeled Trimetazidine dihydrochloride. Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].
性状	Solid
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4. [3]. Chrusciel P, et al. Defining the

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[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
[2]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4.
[3]. Chrusciel P, et al. Defining the

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Trimetazidine-d8 (dihydrochloride)

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