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Trimetazidine dihydrochloride

目录号: PL05439 纯度: ≥99%

Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC50 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

CAS No. :13171-25-0

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中文名称	Trimetazidine dihydrochloride
中文别名	盐酸曲美他嗪;1-[(2,3,4-三甲氧苯基)甲基]-哌嗪盐酸盐;2-甲基-2-氨基丙醇;1-(2,3,4--三甲氧苯甲基)哌嗪二盐酸盐;1-(2,3,4-三甲氧基苯基)哌嗪二盐酸盐;1-（2,3,4-三甲氧基苄基）piperazinedihydrochloride;1-(2,3,4-三甲氧基苄基)哌嗪二盐酸盐;4-溴-2-氟吡啶-3-甲醛;曲美他嗪;曲美他嗪丁二盐酸盐;曲美他嗪系统适应性 EP标准品;盐酸曲美他嗪标准品;三甲氧苄嗪;盐酸曲美他嗪JP;曲美他嗪DIHCL;1-(2,3,4--三甲氧苯甲基)哌嗪二盐酸盐,97%
英文名称	Trimetazidine dihydrochloride
英文别名	1-(2,3,4-Trimethoxybenzyl)piperazine dihydrochloride;TRIMETAZIDINE DI HCL;TRIMETAZIDINE HYDROCHLORIDE;TRIMETAZIDINE 2HCL;1-((2,3,4-trimethoxyphenyl)methyl)-piperazindihydrochloride;1-(2,3,4-trimethoxybenzyl)-piperazindihydrochloride;kyurinett;Trimetazidine dihydrochloride;Trimetazidine (dihydrochloride);Trimetazidine Dihydr;TRIMETAZIDINE HCL;1-(2,3,4-TRIMETHOXYBENZYL)PIPERAZINE DI&;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine,dihydrochloride;s4004;vastarel;Takkmint;Vastarel F;Yoshimilon;Youmetazine;Trimetazidine 3HCl;Trimetajust;Lubomail;Yosimilon;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride;Trimetazidine DiHCl;S 4004;48V6723Z1P;Piperazine, 1-[(2,3,4-trimethoxyphenyl)methyl]-, dihydrochloride;DSSTox_RID_80858;DSSTox_CID_25407;DSSTox_GSID_45407
Cas No.	13171-25-0
分子式	C₁₄H₂₄Cl₂N₂O₃
分子量	339.26
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC50 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

产品详情

Trimetazidine dihydrochloride 是一种选择性的长链 3-ketoyl coenzyme A thiolase 抑制剂，IC₅₀ 值为 75 nM，可抑制游离脂肪酸的 β-氧化。Trimetazidine dihydrochloride 是一种有效的抗心绞痛药和一种细胞保护药，具有抗氧化，抗炎，抗伤害和胃保护作用。Trimetazidine dihydrochloride 诱导自噬，还是一种 HADHA 抑制剂。

生物活性

Trimetazidine dihydrochloride is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC 50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine dihydrochloride is an effective antianginal agent and a cytoprotective drug, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine dihydrochloride triggers autophagy. Trimetazidine dihydrochloride is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor.

性状

Solid

IC50 & Target[1][2]

IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)
β-oxidation
Autophagy
3-hydroxyacyl-CoA dehydrogenase (HADHA)

体外研究(In Vitro)

Trimetazidine (1 μM-100 μM; 24 hours; HUVECs) could enhance the viability of the injured HUVECs induces by oxidation in a certain dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Trimetazidine (5-20 mg/kg; oral administration; 1 hour; Swiss albino male mice) in 10 mg/kg and 20 mg/kg doses significantly raises the seizure-threshold current in the increasing current electroshock seizure (ICES) test in the mice. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Shenghu He, et al. Protective effects of trimetazidine against vascular endothelial cell injury induced by oxidation. Journal of Geriatric Cardiology, December 2008 , Vol 5 No 4.
[2]. Chrusciel P, et al. Defining the role of trimetazidine in the treatment of cardiovascular disorders: some insights on its role in heart failure and peripheral artery disease. Drugs. 2014 Jun;74(9):971-80.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (294.76 mM)DMSO : 25 mg/mL (73.69 mM; Need ultrasonic)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Trimetazidine dihydrochloride

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