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N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide

目录号: PL04480 纯度: ≥99%

TS-011 是 20-羟基二十碳四烯酸合成的选择性抑制剂。

CAS No. :339071-18-0

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中文名称	N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide
中文别名	N-(3-氯-4-吗啉代苯基)-N'-羟基甲脒
英文名称	N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide
英文别名	N'-(3-chloro-4-morpholin-4-ylphenyl)-N-hydroxymethanimidamide;N-(3-Chloro-4-morpholinophenyl)-N'-hydroxyformimidamide;Methanimidamide, N-[3-chloro-4-(4-morpholinyl)phenyl]-N'-hydroxy-;BDBM86694;N'-(3-Chloro-4-morpholinophenyl)-N-hydroxyformamidine;N-(3-Chloro-4-morpholinophenyl)-N-hydroxyformimidamide;(E)-N-(3-chloro-4-Morpholinophenyl)-N'-hydroxyforMiMidaMide
Cas No.	339071-18-0
分子式	C₁₁H₁₄ClN₃O₂
分子量	255.70
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	TS-011 是 20-羟基二十碳四烯酸合成的选择性抑制剂。

产品详情	TS-011 是 20-羟基二十碳四烯酸合成的选择性抑制剂。
生物活性	TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acid synthesis.
性状	Solid
体内研究(In Vivo)	TS-011 is a selective inhibitor of 20-Hydroxyeicosatetraenoic acidsynthesis. TS-011 at a dose of 0.3 mg/kg inhibits the reduction in the blood flow velocities at 1 and 7 h after reperfusion (P<0.001). In addition, TS-011 inhibits the increase in the blood flow velocity at 24 h after reperfusion (P<0.01). TS-011 protects the microvascular perfusion area from the loss observed in vehicle-treated mice. TS-011, at a dose of 0.3 mg/kg, also reduces the infarct volume by almost 40% (P<0.05). In 9 dogs with delayed vasospasm, acute blockade of the synthesis of 20-HETE with TS-011 (1 mg/kg IV) significantly increases the diameter of the basilar artery by 39%. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Marumo T, et al. The inhibitor of 20-HETE synthesis, TS-011, improves cerebral microcirculatory autoregulation impaired by middle cerebral artery occlusion in mice. Br J Pharmacol. 2010 Nov;161(6):1391-402. [2]. Hacein-Bey L, et al. Reversal of delayed vasospasm by TS-011 in the dual hemorrhage dog model of subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2006 Jun-Jul;27(6):1350-4.

溶解度数据	In Vitro: DMSO : 250 mg/mL (977.71 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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