Diltiazem-d3 (hydrochloride)|1217623-80-7|-陌孚医药/Medlife

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Diltiazem-d3 (hydrochloride)

目录号: PL04166

CAS No. :1217623-80-7

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中文名称	Diltiazem-d3 (hydrochloride)
中文别名	[2H3]-地尔硫卓盐酸盐;地尔硫卓-D3盐酸盐[干冰运输]
英文名称	Diltiazem-d3 (hydrochloride)
英文别名	Diltiazem-d3 Hydrochloride Also See: D460623 and D460624;DILTIAZEM-D3 HYDROCHLORIDE;(2S,cis)-3-(Acetyloxy)-5-[(2-dimethylamino-d3)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride;Adizem-d3;Altiazem-d3;CRD-401-d3;Dilzem-d3;Masdil-d3;Zilden-d
Cas No.	1217623-80-7
分子式	C₂₂H₂₇ClN₂O₄S
分子量	454.00
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	Diltiazem-d₃ (hydrochloride) 是 Diltiazem hydrochloride 的氘代物。Diltiazem hydrochloride是钙离子流入抑制剂（缓慢通道阻断剂或钙拮抗剂）。
生物活性	Diltiazem-d 3 (hydrochloride) is the deuterium labeled Diltiazem hydrochloride. Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist)[1][2].
体外研究(In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. [3]. van Breemen C, et al. The mechanism

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