THZ2|1604810-84-5|-陌孚医药/Medlife

您当前的位置：

THZ2

目录号: PL02565 纯度: ≥99%

CAS No. :1604810-84-5

商品编号	规格	价格	会员价
PL02565-5mg	5mg	¥5304.00	请登录
PL02565-10mg	10mg	¥1085.00	请登录
PL02565-50mg	50mg	¥3150.00	请登录
PL02565-100mg	100mg	¥5232.50	请登录
PL02565-10mM*1mLinDMSO	10mM*1mLinDMSO	¥6605.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	THZ2
中文别名	THZ2
英文名称	THZ2
英文别名	THZ2;CDK7-IN-1;N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide;(E)-N-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)-3-(4-(dimethylamino)but-2-enamido)benzamide;THZ 2;THZ-2;BCP24675;S7969
Cas No.	1604810-84-5
分子式	C₃₁H₂₈ClN₇O₂
分子量	566.05
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	THZ2 是有效，选择性的 CDK7 抑制剂，IC₅₀ 值为 13.9 nM。
生物活性	THZ2 is a potent and selective CDK7 inhibitor with an IC 50 of 13.9 nM.
性状	Solid
IC50 & Target[1][2]	CDK7 13.9 nM (IC50) CDK1 96.9 nM (IC5
体外研究(In Vitro)	THZ2 selectively targets CDK7 and potently inhibits the growth of triple-negative but not ER/PR breast cancer cells. THZ2 at low nanomolar doses also efficiently suppresses the clonogenic growth of TNBC cells with IC50 of appr 10 nM. THZ2 induces apoptotic cell death in triple-negative but not ER/PR breast cancer cells or normal human cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	THZ2 (10 mg/Kg) markedly reduces the growth rate of tumors in mice and demonstrates an anti-tumor activity. Compared to vehicle-treated tumors, tumor tissues isolated from mice treated with THZ2 has reduced proliferation and increased apoptosis, as indicated by immunostaining against Ki67 and cleaved Caspase 3 respectively. THZ2 in NOD-SCID mice leads to reduced body weight, suggesting that THZ2 mayt be less well-tolerated in this particular mouse strain. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang Y, et al. CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer. Cell. 2015 Sep 24;163(1):174-186.

溶解度数据	In Vitro: DMSO : 21.67 mg/mL (38.28 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation