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NBTGR

目录号: PL01665 纯度: ≥99%

NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 Ki 值为70 nM。

CAS No. :13153-27-0

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中文名称	NBTGR
中文别名	6-(4-硝基苯硫醇)鸟苷;6-(4-硝基苄硫醇)鸟苷;酸性棕402
英文名称	NBTGR
英文别名	Guanosine,6-S-[(4-nitrophenyl)methyl]-6-thio-;NBTGR;S-(P-NITROBENZYL)-6-THIOGUANOSINE;6-(4-nitrobenzylthio)guanosine;S-(4-nitro-benzyl)-6-thio-guanosine;S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN;NBTG;S-(4-NITROBENZYL)-6-THIOGUANOSINE;2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine;2-AMINO-6-[(4-NITROBENZYL)THIO]-9-BETA-D-RIBOFURANOSYLPURINE;NBTG, NBTGR, 2-Amino-6-[(4-nitrobenzyl)thio]-9-β-D-ribofuranosylpurine;S-(4-Nitrobenzyl)-6-thioguanosine,99%;S-(4-NITROBENZYL)-6-THIOGUANOSINE (NBTG) POTENT ADENOSINE TRAN
Cas No.	13153-27-0
分子式	C₁₇H₁₈N₆O₆S
分子量	434.43
包装储存	Powder -20°C 3 years；4°C 2 years
详情描述	NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 Ki 值为70 nM。

产品详情	NBTGR (p-Nitrobenzylthioguanosine)是核苷转运 (nucleoside transport) 的有效抑制剂;抑制腺苷摄取的 K_i 值为70 nM。
生物活性	NBTGR (p-Nitrobenzylthioguanosine) is a potent inhibitor of nucleoside transport; inhibits adenosine uptake with a K i of 70 nM.
性状	Solid
IC50 & Target[1][2]	Ki: 70 nM (adenosine uptake)
体外研究(In Vitro)	A group of purine ribonucleosides with alkarylmercapto substituents at the purine 6-position are potent inhibitors of several aspects of nucleoside metabolism that involved the transfer of ribosyl groups. NBTGR is one of the compounds that inhibits nucleoside transport by human erythrocytes; initial rates of uridine uptake are reduced to zero upon exposure of cells to 1 μM NBTGR. The inhibitor is firmly bound because repeated washing cannot restore uridine transport capability to NBTGR-treated cells. NBTGR inhibits the influx of uridine, inosine, and cytidine, without inhibiting the uptake of the corresponding bases, or that of D-glucose or L-leucine. Uridine antagonizes the NBTGR inhibition of uidine transport in a concentration-dependent manner. NBTGR and related compounds appear to interact with the mechanism for the facilitated transport of nucleosides.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Turnheim K, et al. Inhibition of adenosine uptake in human erythrocytes by adenosine-5-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine. Biochem Pharmacol. 1978;27(18):2191-7. [2]. Parterson A, et al. Nucleoside Transport II Inhibition by p-Nitrobeazylthiogoanosine and Related Compounds. Can. J. Biochem. 49,271-274 (1971)

溶解度数据	In Vitro: DMSO : 100 mg/mL (230.19 mM; Need ultrasonic)配制储备液

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[1]. Turnheim K, et al. Inhibition of adenosine uptake in human erythrocytes by adenosine-5-carboxamides, xylosyladenine, dipyridamole, hexobendine, and p-nitrobenzylthioguanosine. Biochem Pharmacol. 1978;27(18):2191-7.
[2]. Parterson A, et al. Nucleoside Transport II Inhibition by p-Nitrobeazylthiogoanosine and Related Compounds. Can. J. Biochem. 49,271-274 (1971)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

NBTGR

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