Centhaquin
目录号: PL01577 纯度: ≥99%
CAS No. :57961-90-7
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中文名称
Centhaquin
英文名称
Centhaquin
英文别名
Quinoline,2-[2-[4-(3-methylphenyl)-1-piperazinyl]ethyl]-;2-[2-[4-(3-methylphenyl)piperazin-1-yl]ethyl]quinoline;Centhaquine;2-{2-[4-(3-methylphenyl)piperazin-1-yl]ethyl}quinoline;Centhaquin;Compound-7173;2-[2-[4-(3-Methylphenyl)-1-piperazinyl]ethyl]quinoline
Cas No.
57961-90-7
分子式
C22H25N3
分子量
331.45
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Centhaquine (Centhaquin) 是一种具有研究出血性休克的潜力的试剂。Centhaquine 在出血模型中可以减少全身血管阻力。
生物活性
Centhaquine (Centhaquin; PMZ-2010) is a novel agent has the potential for treatment of  haemorrhagic shock. Centhaquine (Centhaquin; PMZ-2010) can augment cardiac output, reduce systemic vascular resistance in haemorrhagic models.
性状
Solid
体内研究(In Vivo)
Centhaquine (Centhaquin) (intravenous injection, 0.01-1.0 mg/kg; intraduodenal administration 1.0-2.5 mg/kg) lowers the blood pressure and reduced the heart rate of anaesthetized and unanaesthetized (decerebrate) cat in a dose-dependent manner.
Centhaquine (Centhaquin) (intravertebral arterial injection; 5-10 μg) or by topical application to the exposed ventral surface of medulla or floor of the fourth ventricle causes hypotension and bradycardia as well as reduced the excitability of the vasomotor loci.
Centhaquine (Centhaquin;PMZ-2010) (intravenous administration; 0.015mg/kg) can attenuate the deleterious effects of catecholamines, improving both the macro- and microcirculation during CPR.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Srimal RC,et al. Pharmacological studies on 2-(2-(4-(3-methylphenyl)-1-piperazinyl)ethyl) quinoline (centhaquin). I. Hypotensive activity.Pharmacol Res. 1990 May-Jun;22(3):319-29.
[2]. Papalexopoulou K, et al. Centhaquin Effects in a Swine Model of Ventricular Fibrillation: Centhaquin and Cardiac Arrest.Heart Lung Circ. 2017 Aug;26(8):856-863.
溶解度数据
In Vitro: DMSO : 62.5 mg/mL (188.57 mM; Need ultrasonic)配制储备液
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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