PF-4800567 是一种有效、选择性的酪蛋白激酶 1ϵ (CK1ϵ) 抑制剂，IC₅₀ 值为 32 nM，对其选择性是对 CK1δ (IC₅₀，711 nM) 的 20 倍。

PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC 50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC 50 , 711 nM).

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CKIδ 711 nM (IC50)

PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 shows inhibitory activity against CK1? and CK1δ in whole cells, with IC50s of 2.65 and 20.38 μM, respectively. PF-4800567 (0.01-10 μM) blocks CK1?-mediated PER3 nuclear localization mediated by CK1? and suppresses PER2 degradation at 1 μM. In addition, PF-4800567 has little effect on the circadian clock at 32 nM. has not independently confirmed the accuracy of these methods. They are for reference only.

PF-4800567 (100 mg/kg, s.c.) is rapidly absorpted and distributed in plasma and brain of mice. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Walton KM, et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J Pharmacol Exp Ther. 2009 Aug;330(2):430-9.

In Vitro: DMSO : 75 mg/mL (208.44 mM; Need ultrasonic)配制储备液