LF3|664969-54-4|-陌孚医药/Medlife

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LF3

目录号: PL13239 纯度: ≥99%

CAS No. :664969-54-4

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中文名称	LF3
中文别名	LF3
英文名称	LF3
英文别名	LF3;LF-3;N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-1-piperazinecarbothioamide;N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propenyl)-1-piperazinecarbothioamide;4-[(2E)-3-phenylprop-2-en-1-yl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide;1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-;s8474;STK143540;4-[(E)-3-phenylprop-2-enyl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide;LF3, >=98% (HPLC);ST50763308;A16851;4-({[4-((2E)-3-phenyl
Cas No.	664969-54-4
分子式	C₂₀H₂₄N₄O₂S₂
分子量	416.56
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	LF3是β-Catenin/TCF4相互作用的拮抗剂，具有抗肿瘤活性。IC₅₀值为1.65 μM。
生物活性	LF3 is an antagonist of the β-Catenin/TCF4 interaction with antitumor activity; has an IC 50 of 1.65 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 1.65 μM (β-Catenin/TCF4, AlphaScreen), 1.82 μM (β-Catenin/TCF4, ELISA)
体外研究(In Vitro)	LF3 inhibits Wnt/β-catenin signals in cells with exogenous reporters and in colon cancer cells with endogenously high Wnt activity. LF3 also suppresses features of cancer cells related to Wnt signaling, including high cell motility, cell-cycle progression, and the overexpression of Wnt target genes. However, LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. Remarkably, the self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer. Tumor growth is significantly reduced when mice with GFP cells are treated with LF3 at 50 mg/kg. LF3 treatment does not disturb the normal histology of the gut of mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Fang L, et al. A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis. Cancer Res. 2016 Feb 15;76(4):891-901.

溶解度数据	In Vitro: DMSO : 250 mg/mL (600.15 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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