WAY-262611|1123231-07-1|-陌孚医药/Medlife

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WAY-262611

目录号: PL13251 纯度: ≥99%

CAS No. :1123231-07-1

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中文名称	WAY-262611
中文别名	1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺;WAY-262611 抑制剂;WAY-262611
英文名称	WAY-262611
英文别名	4-Piperidinemethanamine, 1-[4-(2-naphthalenyl)-2-pyrimidinyl]-;1-{1-[4-(2-Naphthyl)-2-pyrimidinyl]-4-piperidinyl}methanamine;MAY-262611;WAY 262611;WAY-262611;(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine;C20H22N4;{1-[4-(naphthalen-2-yl)pyrimidin-2-yl]piperidin-4-yl}methanamine;QHLITPHIARVDJI-UHFFFAOYSA-N;BCP10871;BDBM50303037;MAY 262611;AK547007;BC600581;Y1889;({1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}methyl)amine
Cas No.	1123231-07-1
分子式	C₂₀H₂₂N₄
分子量	318.42
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC₅₀ 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。
生物活性	WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate with an EC 50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also a Dkk1 inhibitor.
性状	Solid
IC50 & Target[1][2]	EC50: 0.63 μM (β-Catenin)
体外研究(In Vitro)	WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β-catenin pathway and most likely through inhibition of Dkk-1. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Pelletier JC, et al. (1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine: a wingless beta-catenin agonist that increases bone formation rate. J Med Chem. 2009 Nov 26;52(22):6962-5. [2]. L Enochson, et al. GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition. Osteoarthritis Cartilage. 2014 Apr;22(4):566-77.

溶解度数据	In Vitro: DMSO : ≥ 42 mg/mL (131.90 mM)配制储备液

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