Metolazone|17560-51-9|(美托拉宗; SR-720-22)-陌孚医药/Medlife

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Metolazone (Synonyms: 美托拉宗; SR-720-22)

目录号: PL11876 纯度: ≥99%

CAS No. :17560-51-9

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PL11876-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1414.00	请登录

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中文名称	Metolazone
中文别名	美托拉宗;7-氯-1,2,3,4-四氢-2-甲基-3-(2-甲基苯基)-4-氧代-6-喹唑磺酰胺;美托拉腙;甲醋唑胺;甲苯喹唑酮;甲苯喹唑酮 USP标准品;美托拉;美托拉-D7;美托拉索 EP标准品;美托拉索系统适应性 EP标准品;美托拉宗标准品;米托拉腙;美托拉宗(标准品)
英文名称	Metolazone
英文别名	7-Chloro-2-methyl-4-oxo-3-(o-tolyl)-1,2,3,4-tetrahydroquinazoline-6-sulfonamide;DIULO;METENIX;METOLAZONE;MYKROX;OLDREN;SR-720-22;1,2,3,4-tetrahydro-7-chloro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid;2-methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone;6-quinazolinesulfonamide,7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-toly;7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolines;7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesul;7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamid;7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-tolyl-6-quinazolinesulfonamide;fonamide;metalozone;microx;s720-22;Metolazone-d7;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide;7-chloro-2-methyl-3-(2-methylphenyl)-4-oxo-1,2-dihydroquinazoline-6-sulfonamide;Xuret;Normelan;Zaroxolyn;Metolazona;Metolazonum;Metolazonum [INN-Latin];Metolazona [INN-Spanish];Metalazone;Metolazone (Zaroxolyn);Metolazone(Zaroxolyn);7-Chloro-1,2,3,4-;Metolazone
Cas No.	17560-51-9
分子式	C₁₆H₁₆ClN₃O₃S
分子量	365.83
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Metolazone (SR-720-22) 可抗心力衰竭和高血压。

生物活性

Metolazone (SR-720-22) is primarily used to treat congestive heart failure and high blood pressure.

性状

Solid

体外研究(In Vitro)

Metolazone (SR-720-22) is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities.Metolazone and the other thiazide diuretics inhibit the function of the sodium-chloride symporter, preventing sodium and chloride, and therefore water too, from leaving the lumen to enter the tubule cell. As a result, water remains in the lumen and

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Stern A. Metolazone, a diuretic agent. Am Heart J. 1976 Feb;91(2):262-3.
[2]. Thompson DM. A new antihypertensive: metolazone treatment of hypertension. J Kans Med Soc. 1977 Jul;78(7):337-9, 342.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (273.35 mM)H₂O : < 0.1 mg/mL (insoluble)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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