Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer.
性状
Solid
体外研究(In Vitro)
Protamine sulfate has an inhibitory effect on thrombin in the conversion of fibrinogen to fibrin, and that this inhibition is concentration dependent, partial, and reversible.Protamine sulfate is a 5-kDa cationic polypeptide derived from salmon sperm that can bind negatively charged unfractionated heparin (UFH). Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
ClinicalTrial
参考文献
[1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544.[2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8.
溶解度数据
In Vitro: H2O : 50 mg/mL (Need ultrasonic)In Vivo: