Protamine sulfate (Synonyms: 硫酸鱼精蛋白)
目录号: PL11783
Protamine sulfate 是一个阳性离子肽,具有抗肝素活性,可以中和肝素的抗凝血作用,增强脂质介导的基因转移。
CAS No. :9009-65-8
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中文名称
Protamine sulfate
中文别名
精蛋白硫酸盐;硫酸鲑鱼精蛋白;硫酸鱼精蛋白;硫酸鱼精蛋白 USP标准品;鱼精蛋白硫酸盐;原儿茶醛;硫酸鱼精蛋白标准品(JP)
英文名称
Protamine sulfate
英文别名
Protamines, sulfates;Protamine sulfate;PROTAMINE SULFATE BIOTECH GRADE;Protamine sulfates;angiociclan;dilangio;fluxema;protamine, sulfate;Protamines, sulfates (12C, 14C, 15C);Novo protamine sulfate;Protamine Sulfate, from Salmon
Cas No.
9009-65-8
分子式
号MFCd00132091
包装储存
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
产品详情
Protamine sulfate 是一个阳性离子肽,具有抗肝素活性,可以中和肝素的抗凝血作用,增强脂质介导的基因转移。
生物活性
Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer.
性状
Solid
体外研究(In Vitro)
Protamine sulfate has an inhibitory effect on thrombin in the conversion of fibrinogen to fibrin, and that this inhibition is concentration dependent, partial, and reversible.
Protamine sulfate is a 5-kDa cationic polypeptide derived from salmon sperm that can bind negatively charged unfractionated heparin (UFH). Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Sealed storage, away from moisturePowder -80°C 2 years;-20°C 1 year
ClinicalTrial
参考文献
[1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544.
[2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8.
溶解度数据
In Vitro: H2O : 50 mg/mL (Need ultrasonic)In Vivo:
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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