RI-1|415713-60-9|-陌孚医药/Medlife

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RI-1

目录号: PL10760 纯度: ≥99%

CAS No. :415713-60-9

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中文名称	RI-1
中文别名	3-氯-1-(3,4-二氯苯基)-4-(4-吗啉基)-1H-吡咯-2,5-二酮
英文名称	RI-1
英文别名	RI-1;3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione;3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione;3-Chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione;RAD51 inhibitor 1;RAD51 inhibitor RI-1;S8077,RAD51 inhibitor 1;AK157911;3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-yl-1H-pyrrole-2,5-dione;N-(4-Hydroxy-3-methoxybenzyl)octadecanamide;RAD51 inhibitor(RI-1);C14H11Cl3N2O3;RI 1;BDBM39120;c;cid_1074953
Cas No.	415713-60-9
分子式	C₁₄H₁₁Cl₃N₂O₃
分子量	361.61
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	RI-1 是一种选择性 RAD51 的抑制剂，IC₅₀ 值为 5-30 μM。RI-1 在半胱氨酸 319 处与 RAD51 蛋白表面共价结合。RI-1 通过直接结合到 RAD51 细丝中蛋白质亚基之间的界面的蛋白质表面来灭活 RAD51。RI-1 可以破坏人类细胞中的同源重组。
生物活性	RI-1 is a RAD51 inhibitor, with IC 50 s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells.
性状	Solid
IC50 & Target[1][2]	IC50: 5-30 μM (RAD51)
体外研究(In Vitro)	RI-1 (1-50 μM; 24 h) specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells. RI-1 (5-20 μM; 30 min) inhibits HsRAD51 in a concentration-dependent manner. RI-1 (20 μM; 8 h) disrupts the formation of RAD51 foci after DNA damage in immortalized human fibroblasts. RI-1 (15-25 μM; 24 h) sensitizes human cancer cells (HeLa, MCF-7 and U2OS) to cross-linking chemotherapy. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Budke B, et, al. RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells. Nucleic Acids Res. 2012 Aug;40(15):7347-57. [2]. Shi Y, et, al. DAXX, as a Tumor Suppressor, Impacts DNA Damage Repair and Sensitizes BRCA-Proficient TNBC Cells to PARP Inhibitors. Neoplasia. 2019 Jun;21(6):533-544.

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (92.17 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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