PROTAC IDO1 Degrader-1|2488851-89-2|-陌孚医药/Medlife

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PROTAC IDO1 Degrader-1

目录号: PL10681 纯度: ≥98%

CAS No. :2488851-89-2

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PL10681-10mg	10mg	询价	询价
PL10681-50mg	50mg	询价	询价

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中文名称	PROTAC IDO1 Degrader-1
英文名称	PROTAC IDO1 Degrader-1
英文别名	1,2,5-Oxadiazole-3-carboximidamide, N-(3-bromo-4-fluorophenyl)-4-[[26-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-6,9,12,15,18,21,24-heptaoxa-3-azahexacos-1-yl]amino]-N'-hydroxy-, [C(Z)]-;PROTAC IDO1 Degrader-1;CS-0142810;CHEMBL4750164;AKOS040755760;2488851-89-2;MS-31814;BDBM50562511;HY-131911
Cas No.	2488851-89-2
分子式	C₄₀H₅₃BrFN₉O₁₃
分子量	966.80
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	PROTAC IDO1 Degrader-1 是第一个强效的 IDO1 (indoleamine 2,3-dioxygenase 1) 降解剂，它将IDO1劫持到Cereblon E3连接酶上，最终实现泛素化和降解 (DC₅₀=2.84 μM)。PROTAC-IDO1降解剂-1适度提高H-ER2-CAR-T细胞的杀伤活性。
生物活性	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to Cereblon E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC 50 =2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells.
性状	Solid
IC50 & Target[1][2]	IDO1 2.84 μM (DC50) IDO1 1.07 μM (IC5
体外研究(In Vitro)	PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ. PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24 h, and a significant dose-dependent degradation is observed. PROTAC IDO1 Degrader-1 combined with chimeric antigen receptor-modified T (CAR-T) cells can improve the tumor-killing activity of HER-2 CAR-T cells. PROTAC IDO1 Degrader-1 induces significant and persistent degradation of IDO1 with maximum degradation (dmax) of 93% in HeLa cells. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.

溶解度数据	In Vitro: DMSO : 100 mg/mL (103.43 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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