Pep2m, myristoylated TFA (Myr-Pep2m TFA) 是一种细胞通透性肽。Pep2m, myristoylated TFA 能破坏蛋白激酶 ζ (PKMζ) 下游靶点 NSF/GluR2 相互作用。PKMζ 具有自主活性的 PKC 同工酶。

Pep2m, myristoylated TFA (Myr-Pep2m TFA) is a cell-permeable peptide. Pep2m, myristoylated TFA can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC).

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NSF/GluR2 interactions

Pep2m, myristoylated TFA (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation.
Pep2m, myristoylated TFA does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis.
Pep2m, myristoylated TFA blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture.
has not independently confirmed the accuracy of these methods. They are for reference only.

Pep2m, myristoylated TFA (10 μg/20 μL) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test.
has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

{Myr}-KRMKVAKNAQ

[1]. Yudong Yao, et al. PKMζ Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors. J Neurosci. 2008 Jul 30; 28(31): 7820-7827.
[2]. Nicole C George, et al. Sex differences in the contributions of spinal atypical PKCs and downstream targets to the maintenance of nociceptive sensitization. Mol Pain. 2019; 15: 1744806919840582.

In Vitro: DMSO : 33.33 mg/mL (22.25 mM; Need ultrasonic)H₂O : 3.33 mg/mL (2.22 mM; Need ultrasonic)配制储备液