Pentagamavunon-1|27060-70-4|(PGV-1)-陌孚医药/Medlife

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Pentagamavunon-1 (Synonyms: PGV-1)

目录号: PL07798 纯度: ≥99%

CAS No. :27060-70-4

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中文名称	Pentagamavunon-1
英文名称	Pentagamavunon-1
英文别名	PGV-1;Pentagamavunon-1;2,5-bis(4-hydroxy-3,5-dimethylbenzylidene)cyclopentanone;BDBM50264962;2,5-Bis(3,5-dimethyl-4-hydroxybenzylidene)cyclopentanone;(2E,5E)-2,5-bis[(4-hydroxy-3,5-dimethylphenyl)methylidene]cyclopentan-1-one
Cas No.	27060-70-4
分子式	C₂₃H₂₄O₃
分子量	348.43
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Pentagamavunon-1 (PGV-1) 是Curcumin 的类似物，具有口服活性，通过多个机制诱导凋亡信号，如抑制COX-2 和 VEGF。Pentagamavunon-1 (PGV-1) 可抑制 NF-κB 的激活。
生物活性	Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation.
性状	Solid
体外研究(In Vitro)	Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 μM) enhances cytotoxic effect of 5-FU on WiDr cells. Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 μM) shows different effects on cell cycle progression and induces G2/M arrest. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay.
体内研究(In Vivo)	Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Human cance
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Edy Meiyanto, et al. Curcumin Analog Pentagamavunon-1 (PGV-1) Sensitizes Widr Cells to 5-Fluorouracil Through Inhibition of NF-κB Activation. Asian Pac J Cancer Prev. 2018 Jan 27;19(1):49-56. [2]. Beni Lestari, et al. Pentagamavunon-1 (PGV-1) Inhibits ROS Metabolic Enzymes and Suppresses Tumor Cell Growth by Inducing M Phase (Prometaphase) Arrest and Cell Senescence. Sci Rep . 2019 Oct 16;9(1):14867.

溶解度数据	In Vitro: DMSO : 50 mg/mL (143.50 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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