E3330 (APX-3330) 是一种直接，口服有效的，选择性的 Ape-1 (无嘌呤/嘧啶内切酶 1)/Ref-1 (氧化还原因子 -1) 氧化还原的抑制剂。E3330 能抑制胰腺癌组织中 NF-κB、AP-1、HIF-1α 的活性。E3330 具有抗癌活性。

E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities.

Solid

Ape-1, Ref-1

E3330 (0-50 μM, 48 h) inhibits the growth of HUVECs, PCECs and EPCs.
E3330 (0-5 μM) reduces secreted and intracellular VEGF (vascular endothelial growth factor) expression by pancreatic cancer cells, while concomitantly downregulating the cognate receptor Flk-1/KDR on PCECs.
E3330 (0-1 μM) inhibits the differentiation of bone marrow mesenchymal stem cells (BM-MSCs) into CD31 cells of endothelial lineage.
E3330 (0-50 μM, 72 h) decreases cell viability in H1975 cells about 45% at 50 μM.
E3330 (0-30 μM) inhibits the growth and migration of pancreatic cancer cells.
E3330 (0-30 μM) significantly enhances intracellular ROS level and inhibits CD44 expression in PANC1 cells. has not independently confirmed the accuracy of these methods. They are for reference only.

E3330 (25 mg/kg, Orally, 5 daily, five days each week for three weeks) is neuroprotective against cisplatin-induced alterations in capsaicin-induced vasodilation.
E3330 (0-100 mg/kg, Orally, once) attenuates the liver injury when given at 1 h, 6 h or 12 h after galactosamine challenge. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Zou GM, et al. The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: therapeutic implications in tumor angiogenesis. J Cell Physiol. 2009 Apr;219(1):209-18.
[2]. Manguinhas R, et al. Impact of the APE1 Redox Function Inhibitor E3330 in Non-small Cell Lung Cancer Cells Exposed to Cisplatin: Increased Cytotoxicity and Impairment of Cell Migration and Invasion. Antioxidants (Basel). 2020 Jun 24;9(6):550.

In Vitro: DMSO : 120 mg/mL (317.07 mM; Need ultrasonic)配制储备液