Lidocaine hydrochloride|73-78-9|(盐酸利多卡因; Lignocaine hydrochloride)-陌孚医药/Medlife

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Lidocaine hydrochloride (Synonyms: 盐酸利多卡因; Lignocaine hydrochloride)

目录号: PL07051 纯度: ≥99%

CAS No. :73-78-9

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中文名称	Lidocaine hydrochloride
中文别名	盐酸利多卡因;N-(2,6-二甲苯基)-2-(二乙氨基)乙酰胺盐酸盐;利多卡因;利多卡因盐酸;利多卡因盐酸盐;盐酸利多卡因标准品;盐酸利多卡因欢迎订购;盐酸利多卡因局部麻醉药;盐酸利多卡因原药;原药盐酸利多卡因;2-二乙氨基-N-2,6-二甲苯基乙酰胺氮盐酸盐;克拉维酸锂;盐酸利多卡因BP
英文名称	Lidocaine hydrochloride
英文别名	lidocaine hydrochloride;2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide hydrochloride;Lidocaine HCl;Lignocaine HCl;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide,hydrochloride;Lidocaie Hydrochloride;Lidocaine Hydrochloride Monohydrate;Lignocaine hydrochloride;Laryng-O-jet;Lidocaton;Lidothesin;USP;Xilina hydrochloride;Xylocard;Xyloneural;Lidocaine;Lidocaine hydrochloride
Cas No.	73-78-9
分子式	C₁₄H₂₂N₂O^.HCl
分子量	270.80
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

Lidocaine (Lignocaine) hydrochloride 抑制涉及复杂电压和依赖性的钠通道 (sodium channels)。Lidocaine hydrochloride 通过调节 miR-145 表达和进一步抑制 MEK/ERK 和 NF-κB 信号通路来减少胃癌细胞的生长，迁移和侵袭。Lidocaine 是一种酰胺衍生物，是一种研究室性心律失常的药物和有效的肿瘤抑制剂。

生物活性

Lidocaine hydrochloride (Lignocaine hydrochloride) inhibits sodium channels involving complex voltage and using dependence. Lidocaine hydrochloride decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine hydrochloride is an amide derivative and a drug to treat ventricular arrhythmia and an effective tumor-inhibitor.

性状

Solid

IC50 & Target[1][2]

MEK ERK

体外研究(In Vitro)

Lidocaine hydrochloride (Lignocaine hydrochloride) (10 nM; 48 hours) decreases significantly cell proliferation.
Lidocaine hydrochloride (1-10 nM; 24-72 hours) inhibits cell viability and achieves the most suppressing effects at the concentration of 10?nM and treatment time 48?hours.
Lidocaine hydrochloride (10 nM; 48 hours) increases significantly the apoptotic cell rate.
Lidocaine hydrochloride (10 nM; 48 hours) down-regulates Cyclin D1 and up-regulates p21 expression significantly.
has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Lidocaine hydrochloride (Lignocaine hydrochloride) causes completely reversible tail nerve block in rats. Mechanical nociception block produced by lidocaine has slower onset and faster recovery compared with thermal nociception block. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Cummins TR, et al. Setting up for the block: the mechanism underlying lidocaines use-dependent inhibition of sodium channels. J Physiol. 2007 Jul 1;582(Pt 1):11.
[2]. Sui H, et al. Lidocaine inhibits growth, migration and invasion of gastric carcinoma cells by up-regulation of miR-145. BMC Cancer. 2019 Mar 15;19(1):233.

溶解度数据	In Vitro: H₂O : ≥ 100 mg/mL (369.28 mM)DMSO : ≥ 100 mg/mL (369.28 mM)

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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