ZSET1446|887603-94-3|(ST-101)-陌孚医药/Medlife

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ZSET1446 (Synonyms: ST-101)

目录号: PL07670 纯度: ≥98%

CAS No. :887603-94-3

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中文名称	ZSET1446
中文别名	ST101
英文名称	ZSET1446
英文别名	ZSET 1446;1',3'-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2'-inden]-2-one;ST101;ST-101;ZSET-1446;ZSET1446;7TTT61784C;BCP33073;ST 101(ZSET1446);Spiro(imidazo(1,2-a)pyridine-3(2H),2'-(2H)inden)-2-one, 1',3'-dihydro-;DB12621;SB18912;NS00068496;A13764;Q27268838;spiro[1,3-dihydroindene-2,3'-imidazo[1,2-a]pyridine]-2'-one;1,3-DIHYDRO-2H-SPIRO[IMIDAZO[1,2-A]PYRIDINE-3,2-INDEN];1′,3′-Dihydrospiro[imidazo[1,2-a]pyridine-3(2H),2′-[2H]inden]-2-one (ACI);1′,3′-Dihydro-2H-spiro[imidazo[1,2-a]pyridine-3,2′-inden]-2-one;ST 101
Cas No.	887603-94-3
分子式	C₁₅H₁₂N₂O
分子量	236.27
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

ZSET1446 是一种新颖的促进认知药，在不同的阿尔茨海默病模型中，能够改善学习功能障碍。

生物活性

ZSET1446 is a novel cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.

性状

Solid

体外研究(In Vitro)

ZSET1446 (100 pM-10 nM) exerts limited effects on the basal neuronal excitability and synaptic transmission. ZSET1446 potentiates the facilitatory effect of nAChR stimulation on sPSC frequency. ZSET1446 potentiates the increase in sIPSC frequency by local application of nicotine (5 μM; 2 minutes) without affecting the basal sIPSC frequency at the range of 10 pM to 1 nM. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

ZSET1446 enhances object recognition memory in mice and ameliorates cognitive impairment caused by scopolamine in rats. Concomitant administration of subeffective doses of ZSET1446 and memantine significantly ameliorates the cognitive performance in the novel object recognition task in both mice and rats. Moreover, oral administration of ZSET1446 or memantine increases the extracellular level of ACh in the hippocampus as compared with the control. Further, concomitant administration of subeffective doses of ZSET1446 and memantine significantly increases the extracellular level of ACh as compared with the group of ZSET1446 or memantine alone. ZSET1446 (0.002, 0.01, and 0.1 mg/kg, p.o.) ameliorates cognitive deficits of SAMP8 after 4, 8, 12, and 16 weeks of treatment in a novel object recognition test. ZSET1446 also reduces grading scores of SAMP8 after 16 weeks of treatment. Fu

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Takeda K, et al. Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus. J Pharmacol Exp Ther. 2016 Feb;356(2):445-55
[2]. Yamaguchi Y, et al. Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. J Pharmacol Sci. 2013;123(4):347-55. Epub 2013 Nov 29.

溶解度数据	In Vitro: DMSO : 50 mg/mL (211.62 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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