Pyrantel tartrate|33401-94-4|(酒石酸噻嘧啶)-陌孚医药/Medlife

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Pyrantel tartrate (Synonyms: 酒石酸噻嘧啶)

目录号: PL07678 纯度: ≥98%

CAS No. :33401-94-4

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中文名称	Pyrantel tartrate
中文别名	酒石酸噻吩嘧啶;酒石酸噻嘧啶;噻嘧啶酒石酸
英文名称	Pyrantel tartrate
英文别名	(E)-4,5,6-TETRAHYDRO-1-METHYL-2-(2-(2-THIENYL)ETHENYL)PYRIMIDINE;Pyrantel (+)-tartrate salt;PYRANTEL TARTRATE;PYRANTEL TARTRATE SALT;1-Methyl-2-(2-[2-thienyl]ethenyl)-1,4,5,6-tetrahydropyrimidine;pyrantel hydrogen tartrate;Pyrantel Tartate;Pyranteltartrat;1,4,5,6-Tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)-pyrimidin(e)-pyrimidintartrate;Pyrantel tartrate
Cas No.	33401-94-4
分子式	C₁₁H₁₄N₂S^.C₄H₆O₆
分子量	356.39
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Pyrantel tartrate 是一种口服有效的驱虫剂，也是烟碱乙酰胆碱受体 (nAChR) 激动剂。Pyrantel tartrate 可引起寄生虫的痉挛性肌肉麻痹。Pyrantel tartrate 可用于寄生虫感染的研究，比如蛔虫病、钩虫感染、肠虫病 (蛲虫感染)、毛霉菌病和旋毛虫病。

生物活性

Pyrantel tartrate is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel tartrate can cause spasmodic muscle paralysis in parasites. Pyrantel tartrate can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.

性状

Solid

IC50 & Target[1][2]

Parasites.

体外研究(In Vitro)

Pyrantel tartrate (10 nM-10 μM; 72 h) shows good anti- A. suum and (0-168.2 M; 72 h) anti- N. americanus activity. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay

体内研究(In Vivo)

Pyrantel tartrate (10 mg/kg; p.o.; single) reduces the worms in A. ceylanicum-infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Martin RJ, et, al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90.
[2]. Tritten L, et, al. In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS Negl Trop Dis. 2011 Dec;5(12):e1457.

溶解度数据	In Vitro: DMSO : ≥ 34 mg/mL (95.40 mM)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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