Pozanicline dihydrochloride|161416-61-1|(ABT-089 dihydrochloride)-陌孚医药/Medlife

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Pozanicline dihydrochloride (Synonyms: ABT-089 dihydrochloride)

目录号: PL07658 纯度: ≥97%

CAS No. :161416-61-1

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中文名称	Pozanicline dihydrochloride
中文别名	ABT 089 dihydrochloride
英文名称	Pozanicline dihydrochloride
英文别名	ABT 089 dihydrochloride;2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride;Pozanicline dihydrochloride;Pozanicline (dihydrochloride);Pozanicline hydrochloride;(S)-3-(2-pyrrolidinylmethoxy)-2-picoline dihydrochloride;(S)-3-(2-pyrrolidinylmethoxy)-2-picoline 2HCl;2-Methyl-3-[(2S)-pyrrolidinylmethoxy]pyridine dihydrochloride;2-Methyl-3-[(2S)-2-pyrrolidinylmethoxy]-pyridineDihydrochloride;(S)-2-M;ABT-089 dihydrochloride
Cas No.	161416-61-1
分子式	C₁₁H₁₈Cl₂N₂O
分子量	265.18
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Pozanicline dihydrochloride (ABT-089 dihydrochloride) 是一种具有口服活性的烟碱型乙酰胆碱受体 (nAChR) 激动剂，与 [³H] 胱氨酸位点结合，K_i 为 16.7 nM。Pozanicline dihydrochloride 是一种 α4β2 选择性 nAChR 激动剂，与大鼠脑 α4β2 nAChR 结合，K_i 为 17 nM，而与 α7nAChR 的结合力很弱。

生物活性

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K i of 16.7 nM for binding to [H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K i of 17 nM while binding to α7 nAChR is insignificant.

性状

Solid

体外研究(In Vitro)

Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC50 of 0.11 μM.
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Adult m

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Lin NH, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90
[2]. Marks MJ, et al. Selectivity of ABT-089 for α4β2 and α6β2 nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 1;78(7):795-802.

溶解度数据	In Vitro: H₂O : 100 mg/mL (377.10 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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