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Mivacurium dichloride

(Synonyms: 二氯美维库铵)

目录号: PL07650 纯度: ≥99%

Mivacurium dichloride 是一种苄基异喹啉衍生物，也是一种短效非去极化神经肌肉阻滞剂和骨骼肌松弛剂。Mivacurium dichloride 可与 nAChR 偶联，以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。

CAS No. :106861-44-3

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中文名称	Mivacurium dichloride
中文别名	氯米洼库;米库氯铵;米库氯铵氯化物;2-氟-3-甲酰基-5-氯吡啶;2-甲基丙烯酸环己酯;米库氯胺技术转让;-1,2,3,4-四氢-2-(3-羟丙基)-6,7-二甲氧基-2-甲基-1-(3,4,5-三甲基苄基)异喹啉氯化物(E)-4-辛烯二羧酸(2:1);咪伐氯铵;米伐氯铵;二氯美维库铵
英文名称	Mivacurium dichloride
英文别名	Mivacurium chloride;Mivacurium Chloride (mixture of isomers);[R-[R,R-(E)]]2,2'-(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxyphenyl)isoquinolinium] dichloride;Mivacron;rac-Mivacron;rac-BW-B 1090;rac Mivacurium Chloride;-1,2,3,4-Te．trahydro-2-(3-hydroxypropyl)-6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxy-benzyl)isoquinolinium chloride,(E)-4-octenedioate(2：1);BW-B1090U;rac-BW-B 1090U;Mivacurium dichloride
Cas No.	106861-44-3
分子式	C₅₈H₈₀Cl₂N₂O₁₄
分子量	1100.17
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
详情描述	Mivacurium dichloride 是一种苄基异喹啉衍生物，也是一种短效非去极化神经肌肉阻滞剂和骨骼肌松弛剂。Mivacurium dichloride 可与 nAChR 偶联，以减少或抑制乙酰胆碱对肌肉细胞末端盘的去极化作用。

产品详情

生物活性

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.

性状

Solid

体外研究(In Vitro)

Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature.
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

ClinicalTrial

参考文献

[1]. Delu Che, et al. Mivacurium Induce Mast Cell Activation and Pseudo-Allergic Reactions via MAS-related G Protein Coupled receptor-X2. Cell Immunol. 2018 Oct;332:121-128.
[2]. Matthias Paul, et al. The Potency of New Muscle Relaxants on Recombinant Muscle-Type Acetylcholine Receptors. Anesth Analg. 2002 Mar;94(3):597-603; table of contents.

溶解度数据	In Vitro: DMSO : 250 mg/mL (227.24 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (90.90 mM)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Mivacurium dichloride

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