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JNJ0966

目录号: PL07414 纯度: ≥99%

JNJ0966 是一种高选择性 MMP-9 酶原抑制剂，其 IC50 值为 440 nM。

CAS No. :315705-75-0

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中文名称	JNJ0966
英文名称	JNJ0966
英文别名	JNJ0966;N-(2-((2-methoxyphenyl)amino)-4'-methyl-[4,5'-bithiazol]-2'-yl)acetamide;Oprea1_109350;Oprea1_487426;BCP25926;JNJ 0966;s5696;N-[5-[2-(2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]acetamide;N-(2-(2-Methoxyphenylamino)-4'-methyl-4,5'-bithiazol-2'-yl)acetamide;N-[2-[(2-Me
Cas No.	315705-75-0
分子式	C₁₆H₁₆N₄O₂S₂
分子量	360.45
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	JNJ0966 是一种高选择性 MMP-9 酶原抑制剂，其 IC₅₀ 值为 440 nM。
生物活性	JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC 50 of 440 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 440 nM (MMP-9 zymogen)
体外研究(In Vitro)	JNJ0966 is a highly selective MMP-9 zymogen inhibitor with an IC50 of 440 nM. The activations of proMMP-1, proMMP-2, and proMMP-3 are not significantly different in the presence or absence of 10 μM JNJ0966, whereas proMMP-9 activation by trypsin is significantly attenuated by JNJ0966. The addition of JNJ0966 to the reaction results in a significant reduction in fully processed MMP-9 and an apparent accumulation of the intermediate species. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The exposures of JNJ0966 are dose-dependent, with plasma and brain concentrations for the 10-mg/kg dose of 77.5±31.1 ng/mL (215 nM) and 481.6±162.5 ng/g (~1336 nM), respectively, whereas the 30-mg/kg dose achieves 293.6±118.4 ng/mL (815 nM) in plasma and 1394.0±649.1 ng/g (~3867 nM) in brain. JNJ0966 is preferentially partitioned in brain, with brain/plasma ratios of 6.2 for the 10-mg/kg dose and 4.7 for the 30-mg/kg dose. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Scannevin RH, et al. Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) thatallosterically inhibits zymogen activation. J Biol Chem. 2017 Oct 27;292(43):17963-17974.

溶解度数据	In Vitro: DMSO : 100 mg/mL (277.43 mM; Need ultrasonic)配制储备液

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JNJ0966

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